Genetic mutation

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(Created page with "'''Genetic mutation- '''this term indicates an alteration to base sequence in DNA of an organism which results in a mutant allele of a gene i.e. ...")
 
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'''Genetic mutation- '''this term indicates an alteration to base sequence in [[DNA|DNA]] of an organism which results in a mutant [[Allele|allele]] of a [[Gene|gene]] i.e. an allele that occurs in less than 1% of population.The change is heritable and can be passed on to offspring if fixed into the parental [[Genome|genome]]. Mutations can vary depending on the type of genomic alteration:
+
'''Genetic mutation- '''this term indicates an alteration to base sequence in [[DNA|DNA]] of an organism which results in a mutant [[Allele|allele]] of a [[Gene|gene]] i.e. an allele that occurs in less than 1% of population.The change is heritable and can be passed on to offspring if fixed into the parental [[Genome|genome]]. Mutations can vary depending on the type of genomic alteration:  
  
-addition
+
-addition  
  
-deletion
+
-deletion  
  
-substitution
+
-substitution  
  
-rearrangement of bases.
+
-rearrangement of bases.  
  
 
To investigate the events leading to mutation we can look at mutagenesis process. There are three types:  
 
To investigate the events leading to mutation we can look at mutagenesis process. There are three types:  
  
-spontaneous (no mutation causing agent)
+
-spontaneous (no mutation causing agent)  
  
-induced (a foreign genome introduced e.g.in the laboratory)
+
-induced (a foreign genome introduced e.g.in the laboratory)  
  
-directed (in vitro change to genome).
+
-directed (in vitro change to genome).  
  
<ref>Genetics, 1987, Geoffrey Zubay</ref>
+
<ref>Genetics, 1987, Geoffrey Zubay</ref>  
  
We can calculate the rate of mutation occurance using an equation from Poisson distribution:
+
We can calculate the rate of mutation occurance using an equation from Poisson distribution:  
  
 
'''P<sub>0</sub>=e<sup>-mN</sup>'''<sup></sup>&nbsp;  
 
'''P<sub>0</sub>=e<sup>-mN</sup>'''<sup></sup>&nbsp;  
  
 
+
<br>
  
 
where P<sub>0</sub> is the probability of seeing no mutations, N is the number of cells per culture and m is the mutation rate.  
 
where P<sub>0</sub> is the probability of seeing no mutations, N is the number of cells per culture and m is the mutation rate.  
  
 
<ref>Encyclopedia of Genetics,Volume 3, 2002, S.Brenner,J.H. Miller</ref>
 
<ref>Encyclopedia of Genetics,Volume 3, 2002, S.Brenner,J.H. Miller</ref>

Revision as of 12:08, 23 November 2012

Genetic mutation- this term indicates an alteration to base sequence in DNA of an organism which results in a mutant allele of a gene i.e. an allele that occurs in less than 1% of population.The change is heritable and can be passed on to offspring if fixed into the parental genome. Mutations can vary depending on the type of genomic alteration:

-addition

-deletion

-substitution

-rearrangement of bases.

To investigate the events leading to mutation we can look at mutagenesis process. There are three types:

-spontaneous (no mutation causing agent)

-induced (a foreign genome introduced e.g.in the laboratory)

-directed (in vitro change to genome).

[1]

We can calculate the rate of mutation occurance using an equation from Poisson distribution:

P0=e-mN 


where P0 is the probability of seeing no mutations, N is the number of cells per culture and m is the mutation rate.

[2]


Cite error: <ref> tags exist, but no <references/> tag was found
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