Glomerulus

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The glomerulus is the beginning section of the nephron, in the kidney, made of a globular capilliary network which is wound in a tight knot structure [1]. The glomerulus is surrounded by a cup-like structure made of epithelial cells known as the Bowman's Capsule and it is the first stage of filtration of the blood as it is entering the kidneyUNIQ16f613dfb022d82-nowiki-00000004-QINU2UNIQ16f613dfb022d82-nowiki-00000005-QINU. The space between the capillary network and the capsule is continuous with lumen of the tubular system of the nephron, and is where the filtrate runs through[3]. Coating the capillary network are podocytes, as well as an unusually thick basement membrane[4]Blood from the afferent arteriole enters the glomerulus and is put under high amounts of pressure to force molecules out of the blood stream and into the Bowman's Capsule as the first stage of ultrafiltration. The efferent arteriole has a very narrow lumen, in order to maintain the high pressure created, enough so that it will force molecules out of the plasma into the Bowman's space. Together, the glomerulus and the Bowman's Capsule form what is known as the renal corpuscle [5].


 [6] Image
Image.jpg

References

  1. Grant's Atlas of Anatomy, Thirteenth Edition, 2001. A.M.R.Agur, A.F.Dalley.
  2. Stevens A; Lowe J Human Histology 3rd ed 2005, Elsevier Limited p298
  3. Stevens A; Lowe J Human Histology 3rd ed 2005, Elsevier Limited p298
  4. Stevens A; Lowe J Human Histology 3rd ed 2005, Elsevier Limited p298
  5. Wheater's Functional Histology A Text and Colour Atlas, Fifth Edition 2006. B.Young, J.S.Lowe, A.Stevens, J.W.Heath.
  6. Jonas Coersmeier, image fckLRAvailable from: http://www.probehead.com/log/fckLRDate accessed:17/10/2014
 


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