Glut 4

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Glut4 is a member of the Solute Carrier Family 2 (SLCA2). The protein is encoded by the SLC2A4 gene and is involved in the insulin-dependent trafficking of glucose to the plasma membrane. The protein is crucial to glucose transport and genetic mutations can be involved in Non-Insulin Dependent Diabetes Mellitus (Diabetes)[1]. Glut4 is typically found in skeletal and cardiac muscle, as well as adipose tissue.

In Diabetes, Glut4 mRNA and protein levels decreases in both white and brown adipose tissue[2].

Also see Glut transporter.

References

  1. Bogen JS Aug 2010 http://www.ncbi.nlm.nih.gov/pubmed/20417083
  2. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1130854/
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