Glutamic acid/Glutamate (denoted as Glu or E) is one of the 20 naturally occuring amino acids, and one of the two acidic, negatively charged amino acids, along with Aspartic acid/Aspartate (Asp, or D). The negative charge of E occurs due to the presence of a carboxylic acid group (COOH) in the R chain (as well as with D), which is ionized to it's negative form at physiological pH.
E is encoded genetically by two codons; GAA and GAG.
E has a role in the body as a neurotransmitter, acting on glutamate receptors including the NMDA receptor and playing a role in synaptic plasticity , thought to be important in memory and learning.
- ↑ Bordji K et al.J Neurosci. 2010 Nov 24;30(47):15927-42