Goldman equation

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'''Goldman equation''' is an equation used to calculate the electrical equilibium potential across the cell's membrane in the presence of more than one ions taking into account the selectivity of membrane's permeability. It is derived from the Nernst equation. <br>  
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'''Goldman equation''' is an equation used to calculate the electrical equilibium potential across the [[Cell_membrane|cell's membrane]] in the presence of more than one ions taking into account the selectivity of membrane's permeability. It is derived from the [[Nernst_Equation|Nernst equation]]. <br>
  
== Equation<br> ==
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== Equation<br> ==
  
The Goldman equation can be expressed as follows:<br>  
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The Goldman equation can be expressed as follows:<br>
  
<br>  
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[[Image:Goldman eqn1.png|412x105px|Goldman eqn1.png]]<br>
  
[[Image:Goldman eqn1.png|412x105px]]<br>  
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or<br>
  
or<br>  
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[[Image:Goldman eqn2.png|520x124px|Goldman eqn2.png]]<br>
  
[[Image:Goldman eqn2.png|520x124px]]<br>
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where<br>
 
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<br>
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where<br>
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+
<br>  
+
  
 
E<sub>m</sub> is the potential difference of an ion between membranes  
 
E<sub>m</sub> is the potential difference of an ion between membranes  
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P<sub>A or B </sub>is the permeability of the membrane to a particular ion (A or B)  
 
P<sub>A or B </sub>is the permeability of the membrane to a particular ion (A or B)  
  
[A or B]<sub>o</sub> is the concentration of ion outside the membrane <br>  
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[A or B]<sub>o</sub> is the concentration of ion outside the membrane <br>
  
[A or B]<sub>i</sub> is the concentration of ion inside the membrane<br>  
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[A or B]<sub>i</sub> is the concentration of ion inside the membrane<br>
  
== See also<br> ==
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== See also<br> ==
  
 
*[[Nernst equation]]<br>
 
*[[Nernst equation]]<br>
  
== References<br> ==
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== References<br> ==
  
== External Links ==
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== External Links ==
  
 
*[http://www.nernstgoldman.physiology.arizona.edu/ The Nernst/Goldman Equation Simulator]
 
*[http://www.nernstgoldman.physiology.arizona.edu/ The Nernst/Goldman Equation Simulator]
  
 
<br>
 
<br>

Latest revision as of 10:20, 25 October 2013

Goldman equation is an equation used to calculate the electrical equilibium potential across the cell's membrane in the presence of more than one ions taking into account the selectivity of membrane's permeability. It is derived from the Nernst equation.

Contents

Equation

The Goldman equation can be expressed as follows:

Goldman eqn1.png

or

Goldman eqn2.png

where

Em is the potential difference of an ion between membranes

R is the universal gas constant; R = 8.314471 J mol-1

T is the thermodynamics temperature, in Kelvin; 0 K = -273.15oC

z is the number of moles of electrons transferred between membranes (defined by the valency of ion)

F is the Faraday's constant; F = 96,485.3415 C mol-1

PA or B is the permeability of the membrane to a particular ion (A or B)

[A or B]o is the concentration of ion outside the membrane

[A or B]i is the concentration of ion inside the membrane

See also

References

External Links


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