HDAC

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(Created page with " HDACs are a group of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Enzyme enzymes ]which serve to [https://teaching.ncl.ac.uk/bms/wiki/index.php/Catalysis catalyse] the de...")
 
 
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&nbsp;HDACs are a group of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Enzyme enzymes ]which serve to [https://teaching.ncl.ac.uk/bms/wiki/index.php/Catalysis catalyse] the deacetylation of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Lysine lysine] residues primarily in [https://teaching.ncl.ac.uk/bms/wiki/index.php/Histones histone] proteins. Histone deacetylases serve to reverse the action of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Histone_Acetyl_Transferases histone acetylases] (HATs). As [https://teaching.ncl.ac.uk/bms/wiki/index.php/Acetylation acetylation] serves to increase the expression of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Gene genes] by recruitment of bromodomains, deacetylation serves to decrease expression, therefore increasing repression<ref>Seto E, Yoshida M. Erasers of Histone Acetylation: The Histone Deacetylase Enzymes. Cold Spring Harbor Perspectives in Biology. 2014;6(4):a018713. doi:10.1101/cshperspect.a018713.</ref>.&nbsp;  
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HDACs are a group of [[Enzymes|enzymes]] which serve to [[catalyse|catalyse]] the [[deacetylation|deacetylation]] of [[lysine|lysine]] residues primarily in [[histone|histone]] [[proteins|proteins]]. [[Histone deacetylases|Histone deacetylases]] serve to reverse the action of [[histone acetylases|histone acetylases]] (HATs). As [[acetylation|acetylation]] serves to increase the expression of [[genes|genes]] by recruitment of [[bromodomains|bromodomains]], [[deacetylation|deacetylation]] serves to decrease expression, therefore increasing repression<ref>Seto E, Yoshida M. Erasers of Histone Acetylation: The Histone Deacetylase Enzymes. Cold Spring Harbor Perspectives in Biology. 2014;6(4):a018713. doi:10.1101/cshperspect.a018713.</ref>.&nbsp;  
  
=== '''References''' ===
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=== References  ===
  
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Latest revision as of 17:42, 18 October 2018

HDACs are a group of enzymes which serve to catalyse the deacetylation of lysine residues primarily in histone proteins. Histone deacetylases serve to reverse the action of histone acetylases (HATs). As acetylation serves to increase the expression of genes by recruitment of bromodomains, deacetylation serves to decrease expression, therefore increasing repression[1]

References

  1. Seto E, Yoshida M. Erasers of Histone Acetylation: The Histone Deacetylase Enzymes. Cold Spring Harbor Perspectives in Biology. 2014;6(4):a018713. doi:10.1101/cshperspect.a018713.
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