Half life

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(Created page with "''' Elimination half-life''', written as '''t<sub>1/2</sub>''', is the time needed for the concentration of a substance (usually a drug, metabolite *T...")
 
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'''&nbsp;Elimination half-life''', written as '''t<sub>1/2</sub>''', is the time needed for the concentration of a substance (usually a drug,&nbsp;[[Metabolite|metabolite]]
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'''&nbsp;Elimination half-life''', written as '''t<sub>1/2</sub>''', is the time needed for the concentration of a substance (usually a drug,&nbsp;[[Metabolite|metabolite]]&nbsp;or [[Hormone|hormone]]) to half in the blood plasma.
  
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*The t<sub>1/2</sub> or&nbsp;rate of decay (dC/dt) proportional to [[Concentration|concentration is]] exponential so when trying to measure half-life graphs are usually plotted on a semi-logarithmic scale in order to get a straight line which is easier to manipulate.&nbsp;  
*The t<sub>1/2</sub> or&nbsp;rate of decay (dC/dt) proportional to [[Concentration|concentration ]]is exponential so when trying to measure half-life graphs are usually plotted on a semi-logarithmic scale in order to get a straight line which is easier to manipulate.&nbsp;
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*Half-life is important in [[Pharmacokinetics|pharmacokinetics and]] depends on how quickly the substance is&nbsp;[[Drug elimination|eliminated]]&nbsp;ie. the&nbsp;clearance as well as on&nbsp;[[Volume distribution|volume distribution]].&nbsp;  
*Half-life is important in [[pharmacokinetics|pharmacokinetics ]]and depends on how quickly the substance is&nbsp;[[drug elimination|eliminated]]&nbsp;ie. the&nbsp;clearance as well as on&nbsp;[[volume distribution|volume distribution]].&nbsp;
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*Half-life is important when determining how frequently drugs should be administered.
 
*Half-life is important when determining how frequently drugs should be administered.

Revision as of 23:48, 13 November 2011

 Elimination half-life, written as t1/2, is the time needed for the concentration of a substance (usually a drug, metabolite or hormone) to half in the blood plasma.


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