Hippocampal synaptic plasticity

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Hippocampal synaptic plasticity is the relationship between the neuronal memory and cellular mechanisms and synaptic plasticity of the hippocampus[1]. There are studies present which indicate that suggest hippocampal functions are important for higher cognitive function (e.g. impairment leads to cognitive problems in Huntington's)[2]. However, approaches are being brought in to help repair and improve damage to hippocampal synaptic plasticity - for example, Leptin-deficient mice have shown to have impaired hippocampal synaptic plasticity. Increasing Leptin levels made long-term potentiation possible and improved the memory of the deficient mice[3].

References

  1. https://www.ncbi.nlm.nih.gov/pubmed/16678906
  2. https://www.nature.com/articles/s41467-018-06675-3
  3. https://www.ncbi.nlm.nih.gov/pubmed/16678906
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