Histone Methylation

From The School of Biomedical Sciences Wiki
Jump to: navigation, search

Histone methylation is an epigenetic modification resulting in a change in gene expression. It is a post-translational modification where between one and three methyl groups are added to lysine or arginine residues in a histone tail by the enzyme histone methyltransferase[1]. Note that the number of methyl groups added is significant and may have a different effect on gene expression. Whereas other post-translational modifications such as histone acetylation have a set effect on gene expression, histone methylation can either repress or activate gene expression. This is because methylation does not immediately result in a change in gene expression, but recruits proteins which either stimulate or inhibit transcription, by creating binding sites[2].


  1. Armstrong L. Epigenetics. United States of America: Garland Science; 2014.
  2. Griffiths AJF, Wessler SR, Carroll SB, Doebley J. Introduction to genetic analysis, 11th ed. United States of America: W.H. Freeman and Company; 2015.
Personal tools