Histone variants

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Histone variants are used as a method to regulate transcription. They are encoded by genes that differ from the highly conserved major types and are expressed at very low levels compared to their conventional counterparts. All the conventional histones, except H4, have variants, for example, the conventional histone H2A has the histone variants H2AZ, H2AX and macroH2A. Histone variants confer novel structural and functional properties of the nucleosome which affect the chromatin dynamics.

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