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 Hypoxanthine is a purine naturally found in human body and tends to be a component of nucleic acids[1]. Hypoxanthine also can be founded as intermediates during adenine degradation. Specifically, when purine nucleoside phosphorylates reacts with inosine will create hypoxanthine. Afterward, hypoxanthine is converted into xanthine by xanthine oxidase[2]. Another way that hypoxanthine can formed is from deamination of adenine. This particular formation of hypoxanthine can result in mutation in transcription or DNA replication because hypoxanthine has similar structure to guanine; thus, hypoxanthine will be read as guanine and will form hydrogen bond with cytosine[3].

  1. Jarvis H, Marc O. Biochemical Methods of Estimating the Time Since Death. Human Body Decomposition. 2016;3;53-90.
  2. Paul GW, Christopher JM, Vivienne RW, David RB, Mone Z. Free radical pathways in the inflammatory response. New Comprehensive Biochemistry. 1994;28;361-383.
  3. Berg JM, Tymoczko JL, Stryer L. Mutations Involve Changes in the Base Sequence of DNA. Biochemistry. 2002;527.6
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