Hypoxia inducible factor

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(I have added some more information about HIF and its response to hypoxia. I've added a reference to the diagram used to explain the mechanism of HIF activation)
(Addition of links to other pages too)
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Hypoxia Inducible Factor (HIF) is a [[Heterodimeric transcription factor|heterodimeric transcription factor]] which responds to the relative lowering of the [[Oxygen|oxygen]] concentration in a [[Cells|cell]] ([[Hypoxia|hypoxia]]).<ref>Jennifer E. Ziello, Y. (2017). Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its Potential for Therapeutic Intervention in Malignancy and Ischemia. [online] PubMed Central (PMC). Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140184/ [Accessed 20 Oct. 2017]</ref>.  
 
Hypoxia Inducible Factor (HIF) is a [[Heterodimeric transcription factor|heterodimeric transcription factor]] which responds to the relative lowering of the [[Oxygen|oxygen]] concentration in a [[Cells|cell]] ([[Hypoxia|hypoxia]]).<ref>Jennifer E. Ziello, Y. (2017). Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its Potential for Therapeutic Intervention in Malignancy and Ischemia. [online] PubMed Central (PMC). Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140184/ [Accessed 20 Oct. 2017]</ref>.  
  
Hypoxia can be defined as lowering of oxygen levels compared to sea levels (~20.9%)
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Hypoxia can be defined as lowering of oxygen levels compared to sea levels (~20.9%)  
  
HIFs come in two flavours: '''HIF-α''' (HIF-1α, HIF-2α, HIF-3α) and '''HIF-1β'''.<br>
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HIFs come in two flavours: '''HIF-α''' (HIF-1α, HIF-2α, HIF-3α) and '''HIF-1β'''.<br>  
  
Under normal oxygen levels HIF-1α is constantly made and degraded via [[Ubiquitination|ubiquitination]]. <br>
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Under normal oxygen levels HIF-1α is constantly made and degraded via [[Ubiquitination|ubiquitination]]. <br>  
 
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However, when oxygen levels are low (hypoxia) HIF-1α can escape this translational block so that it’s no longer degraded and is still being made in hypoxia.
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As a result, HIF-1α is stabilsed and able to dimerise with HIF-1β to activate target [[Gene_expression|gene expression]] via recruitment of co-factors.<ref>Kenneth , N.S, Rocha, S. Regulation of gene expression by hypoxia. Biochemical journal. 2008;141(1): 19-29.</ref>
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However, when oxygen levels are low (hypoxia) HIF-1α can escape this translational block so that it’s no longer degraded and is still being made in hypoxia.
  
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As a result, HIF-1α is stabilsed and able to dimerise with HIF-1β to activate target [[Gene expression|gene expression]] via recruitment of [[ATP_chromatin_remodelling|co-factors]].<ref>Kenneth , N.S, Rocha, S. Regulation of gene expression by hypoxia. Biochemical journal. 2008;141(1): 19-29.</ref>
  
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=== Reference  ===
 
=== Reference  ===

Revision as of 20:48, 22 October 2018

Hypoxia Inducible Factor (HIF) is a heterodimeric transcription factor which responds to the relative lowering of the oxygen concentration in a cell (hypoxia).[1].

Hypoxia can be defined as lowering of oxygen levels compared to sea levels (~20.9%)

HIFs come in two flavours: HIF-α (HIF-1α, HIF-2α, HIF-3α) and HIF-1β.

Under normal oxygen levels HIF-1α is constantly made and degraded via ubiquitination.

However, when oxygen levels are low (hypoxia) HIF-1α can escape this translational block so that it’s no longer degraded and is still being made in hypoxia.

As a result, HIF-1α is stabilsed and able to dimerise with HIF-1β to activate target gene expression via recruitment of co-factors.[2]



Reference

  1. Jennifer E. Ziello, Y. (2017). Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its Potential for Therapeutic Intervention in Malignancy and Ischemia. [online] PubMed Central (PMC). Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140184/ [Accessed 20 Oct. 2017]
  2. Kenneth , N.S, Rocha, S. Regulation of gene expression by hypoxia. Biochemical journal. 2008;141(1): 19-29.


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