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Immunoglobulin D (IgD) is an antibody class which in the humoral, specific arm of Immunity. It's main function is as an antigen receptor on B lymphocytes. Because of this, it has very low serum concentrations. IgD and IgM are the only 2 Immunoglobins that are co-expressed.

It is roughly 185 kDa in molecular weight and has 4 domains; 2 δ heavy chains and 2 light chains.

B lymphocytes that co-express IgD and IgM have not undergone class switching. As a result, a long mRNA transcript is produced which, when spliced can produce either of the mRNA molecules responsible for producing IgD or IgM depending where the cuts are made[1].


  1. Murphy, K. Weaver, C. (2016) Janeway's Immunobiology. 8th Edition. New York: Garland Sciences. Chapter 5, Page 195
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