Immunoglobulin E

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This type of antibody is one of 5 main classes. This antibody is involved in allergic reactions and the defence against parasites. IgE does not activate the complement. IgE is always a monomer[1]. The heavy chain associated with IgE is ε (epsilon).

Immunoglobulin E (IgE), in mammals, is the least abundant antibody. They are found on eosinophils, a variety of white blood cells secreted in response to parasitic infections or certain allergic reactions[2].

In response to an antigen, IgE binds to a class of Fc receptors located on the cell surface of mast cells or basophils. Here it is able to act as an antigen receptor where, upon stimulation, cytokines are released to attract white blood cells and antibodies to this site[3][4].


  1. Kenneth Murphy. Janeway's Immunobiology, Eighth Edition, p175
  4. Alberts B; Johnson A; Lewis J; et al. Molecular Biology of The Cell. 6th Edition. New York. Garland Science, Taylor and Francis Group. 2015
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