Inner nuclear membrane

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Inner nuclear membranes are part of the nuclear envelope in cells which contain the DNA of eukaryotes (cells with a membrane nucleus). The membrane is made of two layers, outer and inner, joined in a continuous loop with pores allowing for the transfer of substances into and out of the nucleus. The inner and outer membranes differ in that they do not consist of the same proteins[1].

The inner nuclear membrane contains proteins specific to its function, allowing for structural organisation and support of the organelle. Some of these proteins include nurim, MAN 1, lamin B receptor (LBR), lamina-associated polypeptide (LAP) 1, LAP2 and emerin which are important in the attachment of chromatin and lamins[2]. The lamina, made up of nuclear lamins, is a lattice of protein inside the nucleus and is vital in its support[3].

References

  1. Alberts et al., (2009) Molecular Biology of the Cell, 5th ed.
  2. Homer L. et al (2001) Inner nuclear membrane proteins: functions and targeting, Cell Mol Life Sci., 58(12-13):1741-7
  3. Alberts et. al, 2009, Molecular Biology of the Cell, 5th ed.
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