Insomnia

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Insomia is having a difficulty&nbsp;with falling or staying asleep. It is more common in women <ref>NHS - http://www.nhs.uk/conditions/insomnia/Pages/Introduction.aspx (Last reviewed: 11/09/2009)</ref>.Insomnia can occur if a patient is worried or [http://en.wikipedia.org/wiki/Stress_%28biology%29 stressed], it can lead to daytime tiredness which can cause poor performances at work.&nbsp;A self help measure for trying to avoid Insomnia is to not take naps during the day <ref>http://www.bbc.co.uk/health/physical_health/conditions/insomnia1.shtml</ref><ref>http://hcd2.bupa.co.uk/fact_sheets/html/insomnia.html#3</ref>. <br>
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Insomia is having a difficulty&nbsp;with falling or staying asleep. It is more common in women <ref>NHS - http://www.nhs.uk/conditions/insomnia/Pages/Introduction.aspx (Last reviewed: 11/09/2009)</ref>. Insomnia can occur if a patient is worried or [http://en.wikipedia.org/wiki/Stress_%28biology%29 stressed], it can lead to daytime tiredness which can cause poor performances at work.&nbsp;A self help measure for trying to avoid Insomnia is to not take naps during the day <ref>http://www.bbc.co.uk/health/physical_health/conditions/insomnia1.shtml</ref><ref>http://hcd2.bupa.co.uk/fact_sheets/html/insomnia.html#3</ref>. <br>
  
 
=== Fatal Familial Insomnia  ===
 
=== Fatal Familial Insomnia  ===
  
Fatal Familial Insomnia (FFI) is an extremely rare and devastating condition. As suggested by it's name, FFI is a hereditary disease caused by a mutation in the protein [[Prions|prion]] gene&nbsp;<ref name="A deadly prion disease: fatal familial insomnia.">http://www.ncbi.nlm.nih.gov/pubmed/14713095</ref> and although the onset of the disease is generally around middle age; once symptoms appear death usually occurs within one year.<br>
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Fatal Familial Insomnia (FFI) is an extremely rare and devastating condition. As suggested by it's name, FFI is a hereditary disease caused by a mutation in the [[Protein|protein]] [[Prions|prion]] gene&nbsp;<ref name="A deadly prion disease: fatal familial insomnia.">http://www.ncbi.nlm.nih.gov/pubmed/14713095</ref> and although the onset of the disease is generally around middle age; once symptoms appear death usually occurs within one year.<br>
  
 
Symptoms include&nbsp;<ref name="Early age of onset in fatal familial insomnia. Two novel cases and review of the literature.">http://www.ncbi.nlm.nih.gov/pubmed/15311348</ref>:  
 
Symptoms include&nbsp;<ref name="Early age of onset in fatal familial insomnia. Two novel cases and review of the literature.">http://www.ncbi.nlm.nih.gov/pubmed/15311348</ref>:  
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*Cognitive Decline  
 
*Cognitive Decline  
 
*Loss&nbsp;of Motor Skills
 
*Loss&nbsp;of Motor Skills
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=== Genetic cause&nbsp;<ref>Prusiner S.B.(1994):180 Prion diseases: of humans and animals, London: Royal College of Physicians of London</ref>  ===
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Fatal Familial Insomnia is caused by a change in an amino acid [[Amino acid residues|residue]] at position 178. This change is from a negatively charged [[Aspartic_Acid|aspartic acid]] to an [[Asparagine|asparagine residue]]. In short hand this is written as D178N. However the only change in the amino acid residue structure is a substitution of an oxygen atom for a nitrogen atom.
  
 
=== References:  ===
 
=== References:  ===

Latest revision as of 15:08, 29 November 2012

Insomia is having a difficulty with falling or staying asleep. It is more common in women [1]. Insomnia can occur if a patient is worried or stressed, it can lead to daytime tiredness which can cause poor performances at work. A self help measure for trying to avoid Insomnia is to not take naps during the day [2][3].

Fatal Familial Insomnia

Fatal Familial Insomnia (FFI) is an extremely rare and devastating condition. As suggested by it's name, FFI is a hereditary disease caused by a mutation in the protein prion gene [4] and although the onset of the disease is generally around middle age; once symptoms appear death usually occurs within one year.

Symptoms include [5]:

Genetic cause [6]

Fatal Familial Insomnia is caused by a change in an amino acid residue at position 178. This change is from a negatively charged aspartic acid to an asparagine residue. In short hand this is written as D178N. However the only change in the amino acid residue structure is a substitution of an oxygen atom for a nitrogen atom.

References:

  1. NHS - http://www.nhs.uk/conditions/insomnia/Pages/Introduction.aspx (Last reviewed: 11/09/2009)
  2. http://www.bbc.co.uk/health/physical_health/conditions/insomnia1.shtml
  3. http://hcd2.bupa.co.uk/fact_sheets/html/insomnia.html#3
  4. http://www.ncbi.nlm.nih.gov/pubmed/14713095
  5. http://www.ncbi.nlm.nih.gov/pubmed/15311348
  6. Prusiner S.B.(1994):180 Prion diseases: of humans and animals, London: Royal College of Physicians of London


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