Ion-channel-coupled receptor

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The ion-channel-coupled receptors, also called ligand-gated ion channels, are one of the three main [[Cell membrane receptor|cell membrane receptor]]. They play an important role in the transmission of neuronal signals at the [[synapses |synapses ]]and the [[neuromuscular junction|neuromuscular junctions]] (NMJ).
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The ion-channel-coupled receptors, also called ligand-gated ion channels, are one of the three main [[Cell membrane receptor|cell membrane receptor]]. They play an important role in the transmission of neuronal signals at the [[Synapses|synapses and]] the [[Neuromuscular junction|neuromuscular junctions]] (NMJ).  
  
Depending upon which neurotransmitter they bind, these receptors can be classified as excitatory and inhibitory.
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Depending upon which neurotransmitter they bind, these receptors can be classified as excitatory and inhibitory.  
  
= Excitatory receptors =
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= Excitatory receptors =
  
They are cation channels that depolarize the membrane towards the action potential.
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They are cation channels that depolarize the membrane towards the action potential.  
  
== Nicotinic Acetylcholine receptor (nAChR) ==
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== Nicotinic Acetylcholine receptor (nAChR) ==
  
This cholinergic receptor was the first receptor in history to be indentified and named<ref>Langley, J. N. On the contraction of muscle chiefly in relation to the presence of receptive substances. Part 1. J. Physiol. (Lond.) 36, 347–384 (1907).</ref>. It binds the excitatory neurotrasmitter [[acetylcholine|acetylcholine ]](ACh). They can be found in neurons of the [[Central nervous system|CNS ]]and the [[Autonomic nervous system|ANS]] ganglia, as well as in the muscle cells at the [[neuromuscular junctions|NMJ]].
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This cholinergic receptor was the first receptor in history to be indentified and named<ref>Langley, J. N. On the contraction of muscle chiefly in relation to the presence of receptive substances. Part 1. J. Physiol. (Lond.) 36, 347–384 (1907).</ref>. It binds the excitatory neurotrasmitter [[Acetylcholine|acetylcholine ]](ACh). They can be found in neurons of the [[Central nervous system|CNS and]] the [[Autonomic nervous system|ANS]] ganglia, as well as in the muscle cells at the [[Neuromuscular junctions|NMJ]].  
  
nAChRs are blocked by the snake venom [[alpha-bungarotoxin|alpha-bungarotoxin]] and the poisonous extract [[curare|curare]].
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nAChRs are blocked by the snake venom [[Alpha-bungarotoxin|alpha-bungarotoxin]] and the poisonous extract [[Curare|curare]].  
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'''REFERENCES'''
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<references />

Revision as of 18:36, 13 November 2010

The ion-channel-coupled receptors, also called ligand-gated ion channels, are one of the three main cell membrane receptor. They play an important role in the transmission of neuronal signals at the synapses and the neuromuscular junctions (NMJ).

Depending upon which neurotransmitter they bind, these receptors can be classified as excitatory and inhibitory.

Excitatory receptors

They are cation channels that depolarize the membrane towards the action potential.

Nicotinic Acetylcholine receptor (nAChR)

This cholinergic receptor was the first receptor in history to be indentified and named[1]. It binds the excitatory neurotrasmitter acetylcholine (ACh). They can be found in neurons of the CNS and the ANS ganglia, as well as in the muscle cells at the NMJ.

nAChRs are blocked by the snake venom alpha-bungarotoxin and the poisonous extract curare.


REFERENCES

  1. Langley, J. N. On the contraction of muscle chiefly in relation to the presence of receptive substances. Part 1. J. Physiol. (Lond.) 36, 347–384 (1907).
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