Lagging strand

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The lagging strand is the [[DNA|DNA]] strand replicated in the 3' to 5' direction during DNA [[Dna replication|replication]] from a [[Template strand|template strand]]. It is synthesized in [[Okazaki fragments|fragments]].<ref>Shier D, 2008. Hole's Essentials of Human Anatomy and Physiology, 10th edition. McGraw-Hill.</ref><br>
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The lagging strand is the [[DNA|DNA]] strand replicated in the 3' to 5' direction during DNA [[Dna replication|replication]] from a [[Template strand|template strand]]. It is synthesized in [[Okazaki fragments|fragments]]<ref>Shier D, 2008. Hole's Essentials of Human Anatomy and Physiology, 10th edition. McGraw-Hill.</ref>.
  
Due to the functional restriction of the [[DNA polymerase|DNA polymerase]] not being able to synthesize the chain in 3’ to 5’ direction, on the lagging strand, the synthesis of the chain is discontinuous in the 5’ to 3’ direction. The discontinuous replication results in several short segments which are called [[Okazaki fragments|Okazaki fragments]] <ref>Cassimris L, Vishwanath R L, Plopper G (2011) Lewin’s Cells, Second edition, Sudbury Massachusetts: Jones and Bartlett Publishers</ref>.  
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Due to the functional restriction of the [[DNA polymerase|DNA polymerase]] not being able to synthesize the chain in 3’ to 5’ direction, on the lagging strand, the synthesis of the chain is discontinuous in the 5’ to 3’ direction. The discontinuous replication results in several short segments which are called [[Okazaki fragments|Okazaki fragments]]<ref>Cassimris L, Vishwanath R L, Plopper G (2011) Lewin’s Cells, Second edition, Sudbury Massachusetts: Jones and Bartlett Publishers</ref>.  
  
The lagging strand causes the formation of the "trombone model" as the lagging strand is looped during replication.&nbsp;
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The lagging strand causes the formation of the "trombone model" as the lagging strand is looped during replication.  
  
 
=== References  ===
 
=== References  ===
  
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Latest revision as of 12:11, 3 December 2018

The lagging strand is the DNA strand replicated in the 3' to 5' direction during DNA replication from a template strand. It is synthesized in fragments[1].

Due to the functional restriction of the DNA polymerase not being able to synthesize the chain in 3’ to 5’ direction, on the lagging strand, the synthesis of the chain is discontinuous in the 5’ to 3’ direction. The discontinuous replication results in several short segments which are called Okazaki fragments[2].

The lagging strand causes the formation of the "trombone model" as the lagging strand is looped during replication.

References

  1. Shier D, 2008. Hole's Essentials of Human Anatomy and Physiology, 10th edition. McGraw-Hill.
  2. Cassimris L, Vishwanath R L, Plopper G (2011) Lewin’s Cells, Second edition, Sudbury Massachusetts: Jones and Bartlett Publishers
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