Leber’s hereditary optic neuropathy (LHON)

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Leber's hereditary optic neuropathy (LHON)

LHON is a form of vision loss and it is a result of atrophy of the optic nerve, the nerve that transmits messages containing visual information from the eyes to the brain. LHON is a mitochondrial disease in which mutations occur in the MT-ND1, MT-ND4, MT-ND4L, and MT-ND6 genes.[1] It is a disease that affects young adults, predominantly males (very unlikely for LHON to appear in childhood). The vision loss may start in one eye or both eyes at the same time.  As the disease progress, the individual will lose his ability to read, drive and recognizing faces. [2]

 LHON plus

LHON puls has some additional features besides the vision loss such as: the incapability of doing certain movements, tremor and heart arrhythmias. These features are similar to multiple sclerosis, a chronic disorder.[3] Currently, there is no cure for this disease. Further reseach needs to be made in order for us to obtain a better understanding of LHON.


References

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  1. This is a reference to the website of "National Centre for Advancing Translational Science", "Genetic and Rare diseases Information Centre" section.
  2. This is a reference to the website of "U.S. National Library of Medicine"- Genetic Home Reference
  3. This is a reference to the website of "National Centre for Biotechnology Information (NCBI)"
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