Ligand-gated sodium channels

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(Added the references correctly, that is, I added them as explained in the lecture. Cleaned up the text.)
 
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Ligand-gated Na+ channels are found in the postsynaptic membrane of the neuromuscular junction<ref name="al">Alberts, et al. Essential Cell Biology. 4th edition. Abingdon. Garland Science. Page 410-412</ref>. After a neurotransmitter (acetylcholine) binds to its receptor the channel opens (undergoes a conformational change) allowing Na<sup>+</sup> to enter the motor endplate and K<sup>+</sup> to flow out<ref name="al">Alberts, et al. Essential Cell Biology. 4th edition. Abingdon. Garland Science. Page 410-412</ref><ref>Mheducationcom. Animation: Receptors Linked to a Channel Protein. [Accessed 5 December 2017]. Available from: http://highered.mheducation.com/sites/0072495855/student_view0/chapter2/animation__receptors_linked_to_a_channel_protein.html</ref>. This causes the motor endplate to depolarise. If the end plate potential reaches a high enough potential it will go on to trigger an action potential in the cell<ref name="al">Alberts, et al. Essential Cell Biology. 4th edition. Abingdon. Garland Science. Page 410-412</ref>.  
 
Ligand-gated Na+ channels are found in the postsynaptic membrane of the neuromuscular junction<ref name="al">Alberts, et al. Essential Cell Biology. 4th edition. Abingdon. Garland Science. Page 410-412</ref>. After a neurotransmitter (acetylcholine) binds to its receptor the channel opens (undergoes a conformational change) allowing Na<sup>+</sup> to enter the motor endplate and K<sup>+</sup> to flow out<ref name="al">Alberts, et al. Essential Cell Biology. 4th edition. Abingdon. Garland Science. Page 410-412</ref><ref>Mheducationcom. Animation: Receptors Linked to a Channel Protein. [Accessed 5 December 2017]. Available from: http://highered.mheducation.com/sites/0072495855/student_view0/chapter2/animation__receptors_linked_to_a_channel_protein.html</ref>. This causes the motor endplate to depolarise. If the end plate potential reaches a high enough potential it will go on to trigger an action potential in the cell<ref name="al">Alberts, et al. Essential Cell Biology. 4th edition. Abingdon. Garland Science. Page 410-412</ref>.  
  
=== References ===
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=== References ===
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Latest revision as of 09:17, 6 December 2017

Ligand-gated Na+ channels are found in the postsynaptic membrane of the neuromuscular junction[1]. After a neurotransmitter (acetylcholine) binds to its receptor the channel opens (undergoes a conformational change) allowing Na+ to enter the motor endplate and K+ to flow out[1][2]. This causes the motor endplate to depolarise. If the end plate potential reaches a high enough potential it will go on to trigger an action potential in the cell[1].

References

  1. 1.0 1.1 1.2 Alberts, et al. Essential Cell Biology. 4th edition. Abingdon. Garland Science. Page 410-412
  2. Mheducationcom. Animation: Receptors Linked to a Channel Protein. [Accessed 5 December 2017]. Available from: http://highered.mheducation.com/sites/0072495855/student_view0/chapter2/animation__receptors_linked_to_a_channel_protein.html
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