MHC Molecules

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*They present exogenous [[Antigens|antigens]] (those made outside the cell). They bind peptides 18-20 [[Amino acids|amino acids]] long.  
 
*They present exogenous [[Antigens|antigens]] (those made outside the cell). They bind peptides 18-20 [[Amino acids|amino acids]] long.  
 
*Presentation of MHC class II molecules: antigen is endocytosed into a vesicle, protein within this vesicle is cleaved into peptides by an acidic protease, MHC Class II is engulfed into a vesicle, and has an invariant chain bound in peptide binding groove, this is broken down leaving [[CLIP|CLIP]]. [[CLIP|CLIP]] is removed by HLA-DM, and this allows the peptide in the other vesicle to bind, once it has bound.  
 
*Presentation of MHC class II molecules: antigen is endocytosed into a vesicle, protein within this vesicle is cleaved into peptides by an acidic protease, MHC Class II is engulfed into a vesicle, and has an invariant chain bound in peptide binding groove, this is broken down leaving [[CLIP|CLIP]]. [[CLIP|CLIP]] is removed by HLA-DM, and this allows the peptide in the other vesicle to bind, once it has bound.  
*Unlike MHC Class 1 receptors, these molecules have two alpha and two beta subunits, with transmembrane spanning regions from alpha-2 and beta-2. The alpha-1 and beta-1 subunits form an antigen presenting site. 
+
*Unlike MHC Class 1 receptors, these molecules have two alpha and two beta subunits, with transmembrane spanning regions from alpha-2 and beta-2. The alpha-1 and beta-1 subunits form an antigen presenting site.   
 
*In humans the MHC Class II protein has three forms: HLA-DR, HLA-DP and HLA-DQ
 
*In humans the MHC Class II protein has three forms: HLA-DR, HLA-DP and HLA-DQ
  

Revision as of 18:04, 24 October 2017

Major Histocompatibility Complex (MHC) bind peptide fragments from pathogens, and present them on the cell surface to be detected by T cells [1]. There are 2 types of MHC Molecule: Class 1 MHC and Class 2 MHC:

MHC Class 1

MHC Class 2

References

  1. Murphy K. Weaver C. Janeway's Immunobiology. 9th Edition. Garland Science, Taylor and Francis Group. New York and London. 2016.
  2. Mayer G, Nyland J. Major Histocompatibility Complex(MHC)and T-cell receptors - role in immune response. 2017 [cited 19.10.17]. Available from: http://www.microbiologybook.org/bowers/mhc.htm
  3. Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 6th Ed, Abingdon: Garland Science, Taylor and; Francis Group. 2015.
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