Macrophage

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A cellular element of the [[Innate immune system|innate immune system]], these phagocytic [[White blood cells|white blood cells]] are the first&nbsp;to respond&nbsp;to infection. They also play a role in [[Immune_response|inflammation ]]of tissues. When activated, they&nbsp;become [[Antigen presenting cells|antigen presenting cells]] as well as producing [[Chemokines|chemokines]] and [[Cytokines|cytokines]]&nbsp;<ref>Janeways ImmunoBiology, Murphy K. et al., 2008, 7th ed.</ref>.  
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A cellular element of the [[Innate immune system|innate immune system]], these phagocytic [[White blood cells|white blood cells]] are the first&nbsp;to respond&nbsp;to infection. They also play a role in [[Immune response|inflammation of]] tissues. When activated, they&nbsp;become [[Antigen presenting cells|antigen presenting cells]] as well as producing [[Chemokines|chemokines]] and [[Cytokines|cytokines]]&nbsp;<ref>Janeways ImmunoBiology, Murphy K. et al., 2008, 7th ed.</ref>. They work by engulfing pathogens detected by the immune system and engulfing them. The newly engulfed pathogen is then bound to a [[Phagosome|phagosome]] and [[Lysosome|lysosome]] which release enzymes and toxic chemicals that digest the pathogen.
  
 
=== References  ===
 
=== References  ===
  
 
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Revision as of 11:50, 20 October 2014

A cellular element of the innate immune system, these phagocytic white blood cells are the first to respond to infection. They also play a role in inflammation of tissues. When activated, they become antigen presenting cells as well as producing chemokines and cytokines [1]. They work by engulfing pathogens detected by the immune system and engulfing them. The newly engulfed pathogen is then bound to a phagosome and lysosome which release enzymes and toxic chemicals that digest the pathogen.

References

  1. Janeways ImmunoBiology, Murphy K. et al., 2008, 7th ed.
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