Major histocompatibility complex

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Major histocompatibility complexes (MHC) are described as glycoproteins that present a cleaved version of an antigen from an invading organism (epitope). This enables a specific type of T cell to  bind to the antigen and go on to kill all cells displaying this antigen[1]. These cell surface complexes have two classes, I and II. MHC class I contains alpha 1, 2 and 3 domains and a Beta-2 microglobulin, MHC class II molecule contains alpha 1 and 2 and beta 1 and 2 (no microglobulin present)[2]


  1. Berg, J. Stryer, L. Tymoczko, J. (2015)fckLRBiochemistry, Eighth Edition, New York: W.H Freeman and company. Chapter 34, Page 984.
  2. Janeway CA Jr, Travers P, Walport M, Et al. (2001)fckLRImmunobiology: The Immune System In Health & Disease. 5th Edition. New York, Garland Science. Chapter 5.
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