Methylation

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Methylation is a form of [[Alkylation|alkylation]], i.e. the transfer of an [[Alkyl group|alkyl group]] to another [[Molecule|molecule]] . Methylation is specifically the addition or substition of a [[Methyl|methyl group]] to a molecule. [[Methyl groups|Methyl groups]] are alkyls made from [[Methane|methane]] and are [[Carbon|carbon]] [[Atoms|atoms]] attached to 3 [[Hydrogen|hydrogen]] atoms -CH<sub>3</sub>&nbsp;<ref>March's Advanced Organic Chemistry. Michael B. Smith, Jerry March - John Wiley &amp;amp;amp;amp;amp; Sons (2007)</ref>. It can be involved in the [[Gene expression|expression of genes]], as well as [[Protein|protein]] function regulation and the metabolism of [[RNA|RNA]].&nbsp;An example of this is the tri-methylation of lysine 36 on the H3 protein (of a histone), which is involved in the response of plants to necrotrophic fungal attack<ref>http://www.plantphysiol.org/content/154/3/1403</ref>.&nbsp;
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Methylation is a form of [[Alkylation|alkylation]], i.e. the transfer of an [[Alkyl group|alkyl group]] to another [[Molecule|molecule]] . Methylation is specifically the addition or substition of a [[Methyl|methyl group]] to a molecule. [[Methyl groups|Methyl groups]] are alkyls made from [[Methane|methane]] and are [[Carbon|carbon]] [[Atoms|atoms]] attached to 3 [[Hydrogen|hydrogen]] atoms -CH<sub>3</sub><ref>March's Advanced Organic Chemistry. Michael B. Smith, Jerry March - John Wiley &amp;amp;amp;amp;amp;amp; Sons (2007)</ref>. It can be involved in the [[Gene expression|expression of genes]], as well as [[Protein|protein]] function regulation and the metabolism of [[RNA|RNA]].&nbsp;An example of this is the tri-methylation of lysine 36 on the H3 protein (of a histone), which is involved in the response of plants to necrotrophic fungal attack<ref>http://www.plantphysiol.org/content/154/3/1403</ref>.&nbsp;  
  
 
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=== References  ===
  
 
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Revision as of 12:05, 6 December 2018

Methylation is a form of alkylation, i.e. the transfer of an alkyl group to another molecule . Methylation is specifically the addition or substition of a methyl group to a molecule. Methyl groups are alkyls made from methane and are carbon atoms attached to 3 hydrogen atoms -CH3[1]. It can be involved in the expression of genes, as well as protein function regulation and the metabolism of RNA. An example of this is the tri-methylation of lysine 36 on the H3 protein (of a histone), which is involved in the response of plants to necrotrophic fungal attack[2]

References

  1. March's Advanced Organic Chemistry. Michael B. Smith, Jerry March - John Wiley &amp;amp;amp;amp;amp; Sons (2007)
  2. http://www.plantphysiol.org/content/154/3/1403
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