Michaelis constant

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K<sub>m</sub> = Michaelis constant
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K<sub>m</sub> = Michaelis constant  
  
 
K<sub>m</sub> = the value of [S] that causes V= ½ V<sub>max</sub> *  
 
K<sub>m</sub> = the value of [S] that causes V= ½ V<sub>max</sub> *  
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The units of K<sub>m</sub> are M, concentration  
 
The units of K<sub>m</sub> are M, concentration  
  
K<sub>m</sub> indicates the affinity of the enzyme for it's substrate and thus the stability of the [[Enzyme-Substrate Complex|Enzyme-Substrate Complex]].  
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K<sub>m</sub> indicates the affinity of the enzyme for its substrate and thus the stability of the [[Enzyme-Substrate Complex|Enzyme-Substrate Complex]].  
  
 
High K<sub>m</sub> demonstrates a low affinity; Low Km demonstrates a high affinity.  
 
High K<sub>m</sub> demonstrates a low affinity; Low Km demonstrates a high affinity.  
  
velocity is related to K<sub>m&nbsp;</sub>through the Michaelis &amp; Menten equation:&nbsp;v = (V<sub>max</sub> [S])/(K<sub>m</sub> + [S])<br>  
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Velocity is related to K<sub>m&nbsp;</sub>through the Michaelis &amp; Menten equation:&nbsp;v = (V<sub>max</sub> [S])/(K<sub>m</sub> + [S])<br>  
  
 
*V<sub>max</sub> = maximum rate of reaction achievable for the enzyme under given conditions, only occurs at infinite substrate concentration
 
*V<sub>max</sub> = maximum rate of reaction achievable for the enzyme under given conditions, only occurs at infinite substrate concentration
  
 
[S] = substrate concentration<br>
 
[S] = substrate concentration<br>

Revision as of 19:34, 30 November 2015

Km = Michaelis constant

Km = the value of [S] that causes V= ½ Vmax *

The units of Km are M, concentration

Km indicates the affinity of the enzyme for its substrate and thus the stability of the Enzyme-Substrate Complex.

High Km demonstrates a low affinity; Low Km demonstrates a high affinity.

Velocity is related to Kthrough the Michaelis & Menten equation: v = (Vmax [S])/(Km + [S])

[S] = substrate concentration

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