Monogenic disease

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(Created page with "A monogenic disease is caused by a defect or mutation in a single gene. They can be Dominant, Recessive or X-linked. Dominant diseases (e.g. Huntington's) are monogenic disorde...")
 
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A monogenic disease is caused by a defect or mutation in a single gene. They can be Dominant, Recessive or X-linked.  
 
A monogenic disease is caused by a defect or mutation in a single gene. They can be Dominant, Recessive or X-linked.  
  
Dominant diseases (e.g. Huntington's) are monogenic disorders where there is damage to only <u>'''one'''</u> allele.
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Dominant diseases (e.g. Huntington's) are monogenic disorders where there is damage to only <u>'''one'''</u> allele.  
  
Recessive diseases such as Cystic Fibrosis, are monogenic disorders that occur due to damages in <u>'''both'''</u> alleles.
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Recessive diseases such as Cystic Fibrosis, are monogenic disorders that occur due to damages in <u>'''both'''</u> alleles.  
  
X-linked diseases (e.g. Duchenne Muscular Dystrophy) are caused by mutations on an X chromosome (NB women have XX, men have XY)
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X-linked diseases (e.g. Duchenne Muscular Dystrophy) are caused by mutations on an X chromosome (NB women have XX, men have XY)  
  
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Although relatively rare, monogenic diseases affect millions of people world wide as the conditions can be passed on to subsequent generations.<ref>World Health Organisation</ref><br>
  
Although relatively rare, monogenic diseases affect millions of people world wide as the conditions can be passed on to subsequent generations.<ref>http://www.who.int/genomics/public/geneticdiseases/en/index2.html</ref><br>
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Revision as of 16:45, 21 October 2012

A monogenic disease is caused by a defect or mutation in a single gene. They can be Dominant, Recessive or X-linked.

Dominant diseases (e.g. Huntington's) are monogenic disorders where there is damage to only one allele.

Recessive diseases such as Cystic Fibrosis, are monogenic disorders that occur due to damages in both alleles.

X-linked diseases (e.g. Duchenne Muscular Dystrophy) are caused by mutations on an X chromosome (NB women have XX, men have XY)


Although relatively rare, monogenic diseases affect millions of people world wide as the conditions can be passed on to subsequent generations.[1]




Cite error: <ref> tags exist, but no <references/> tag was found
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