Morpholino

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*attaches to [[MRNA|mRNA]], pre/mature, to cause [[Gene knockdown|gene knockdown]]  
 
*attaches to [[MRNA|mRNA]], pre/mature, to cause [[Gene knockdown|gene knockdown]]  
*Used as gene knockdown tool on[[ Zebra fish|Zebra fish]]<ref>Shukla, Arun K., editor. “The Zebrafish: Disease Models and Chemical Screens.” Methods in Cell Biology, vol. 105, no. 12, 2011, pp. 273–308., doi:10.1016/c2009-0-62387-4.</ref>
+
*Used as gene knockdown tool on&nbsp;[[Zebra fish|Zebra fish]]<ref>Shukla, Arun K., editor. “The Zebrafish: Disease Models and Chemical Screens.” Methods in Cell Biology, vol. 105, no. 12, 2011, pp. 273–308., doi:10.1016/c2009-0-62387-4.</ref>
  
 
==== On mature mRNA:  ====
 
==== On mature mRNA:  ====
  
*attaches to AUG blocking [[ribosome|ribosome]] interaction
+
*attaches to AUG blocking [[Ribosome|ribosome]] interaction
  
 
==== On pre-mRNA:  ====
 
==== On pre-mRNA:  ====
  
*sits on splice site, an [[intron-exon junction|intron-exon junction]], making a double-stranded RNA, blocking [[Spliceosome|spliceosome]] which will create truncated/no [[protein|protein]]<br>
+
*sits on splice site, an [[Intron-exon junction|intron-exon junction]], making a double-stranded RNA, blocking [[Spliceosome|spliceosome]] which will create truncated/no [[Protein|protein]]<br>
  
 
=== References  ===
 
=== References  ===

Latest revision as of 17:17, 16 November 2017

Contents

Description

Function

On mature mRNA:

On pre-mRNA:

References

  1. Shukla, Arun K., editor. “The Zebrafish: Disease Models and Chemical Screens.” Methods in Cell Biology, vol. 105, no. 12, 2011, pp. 273–308., doi:10.1016/c2009-0-62387-4.
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