Nernst Equation

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== See also  ==
 
== See also  ==
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*[[Membrane potential]]<br>
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*[[Goldman equation]]<br>
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== References &amp; Notes<br>  ==
 
== References &amp; Notes<br>  ==

Revision as of 15:06, 15 November 2010

Nernst Equation is an equation used to calculate the electrical potential of a chemical reaction. In its equilibrium state, the Nernst equation should be zero. It also shows the direct relation between energy or potential of a cell and its participating ions. The equation is proposed by a German chemist, Walther H. Nernst (1864-1941).[1]

Contents

Equation

Nernst equation can be expressed as follows:

Nernst equation1.png

where

Ecell is the half-cell potential difference

Eθcell is the standard half-cell potential

R is the universal gas constant; R = 8.314471 J K-1 mol-1

T is the thermodynamics temperature, in Kelvin; 0 K = -273.15oC

z is the number of moles of electrons transferred between cells (defined by the valency of ions)

F is the Faraday's constant; F = 96,485.3415 C mol-1

[red] is the concentration of ion that gained electrons (reduction)

[oxi] is the concentration of ion that lost electrons (oxidation)

Membrane potential

Main article: Membrane potential

Nernst equation is also can be used to calculate the potential of an ion across the membrane. For potential difference of a membrane, we can manipulate the Nernst Equation as follows:

Nernst equation2.png

or

Nernst equation3.png

where

Em is the potential difference of an ion between membranes

R is the universal gas constant; R = 8.314471 J mol-1

T is the thermodynamics temperature, in Kelvin; 0 K = -273.15oC

z is the number of moles of electrons transferred between membranes (defined by the valency of ion)

F is the Faraday's constant; F = 96,485.3415 C mol-1

[A-] is the concentration of ion outside the membrane (in this case is anion, negative charge ion)

[A-] is the concentration of ion inside the membrane (in this case is anion, negative charge ion)

Application

Ussing study of frog skin

In biochemistry, Nernst equation can be used to calculate the potential difference of ion between membranes. Hans H. Ussing, a Danish scientist, used a frog skin to measure the potential difference of sodium and potassium ions across the membranes with his famous invention, the Ussing chamber.

Ussing model of transepithelial ions absorption.

[2]Ussing model of transepithelial ions absorption.

For example at the standard condition and temperature of 25oC (298K), the above sodium ion membrane potential can be calculated as:

Nernst equation4.png


Goldman equation

Main article: Goldman equation

In presence of more than one ion, the Nernst equation can be modified into Hodgkin-Katz-Goldman equation or is commonly known as Goldman equation. Goldman equation is proposed by David E. Goldman of Columbia University together with Alan L. Hodgkin and Bernard Katz.

See also



References & Notes

  1. http://nobelprize.org/nobel_prizes/chemistry/laureates/1920/nernst-bio.html, The Nobel Prize in Chemistry 1920; Walther Nernst
  2. Diagram based on CMB2003: Cell and Membrane Transport lecture note (2010).


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