The tight occluding junction is composed of thin bands of plasma membrane proteins; occludin and claudin that circulate the cell where rows of the particles are donated by each cell. The cells are closely connected which prevents membrane proteins or glycolipids to pass through the intercellular space, this barrier then contributes to the epithelial cells ability to control their polarity. The tight junction is located between the epithelial cells below the apical surface as well as connecting to the cell matrix which overall contributes to the separation of the extracellular fluids.
- ↑ Lodish H. Molecular cell biology. 8th ed. New York: W. H. Freeman and Co.; 2016. p.933.