Okasaki fragments

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Okasaki fragments are fragments of [[DNA|DNA]] formed on the lagging strand during bidirectional semiconservative [[DNA replication|DNA replication]]. The strands are later fused together by [[DNA ligase|DNA ligase]] to form the full, unfragmented DNA strand.<ref>Sakabe K, Okazaki R (December 1966). "A unique property of the replicating region of chromosomal DNA". Biochimica et Biophysica Acta 129 (3): 651–54. doi:10.1016/0005-2787(66)90088-8. PMID 5337977.</ref>&nbsp;Each new origin of replication (where the [[DNA polymerase|DNA polymerase]] joins) requires a separate RNA primer.&nbsp;  
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Okasaki fragments are short fragments of [[DNA|DNA]] formed on the lagging strand during bidirectional semiconservative [[DNA replication|DNA replication]]. The strands are later fused together by [[DNA ligase|DNA ligase]] to form the full, unfragmented DNA strand.<ref>Sakabe K, Okazaki R (December 1966). "A unique property of the replicating region of chromosomal DNA". Biochimica et Biophysica Acta 129 (3): 651–54. doi:10.1016/0005-2787(66)90088-8. PMID 5337977.</ref>&nbsp;Each new origin of replication (where the [[DNA polymerase|DNA polymerase]] joins) requires a separate RNA primer.&nbsp;  
  
 
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Revision as of 15:03, 1 December 2015

Okasaki fragments are short fragments of DNA formed on the lagging strand during bidirectional semiconservative DNA replication. The strands are later fused together by DNA ligase to form the full, unfragmented DNA strand.[1] Each new origin of replication (where the DNA polymerase joins) requires a separate RNA primer. 

References:

  1. Sakabe K, Okazaki R (December 1966). "A unique property of the replicating region of chromosomal DNA". Biochimica et Biophysica Acta 129 (3): 651–54. doi:10.1016/0005-2787(66)90088-8. PMID 5337977.
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