Oxidative phosphorylation

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Oxidative phosphorylation is one of the ATP generating processes in the cell. Understanding of this operation is based on chemiosmotic hypothesis (or Mitchell hypothesis) which clarifies how the free energy from electron transport chain across the inner mitochondrial membrane is used to produce ATP.<ref>Pamela C.Champe, Richard A.Harvey, Denise r.Ferrier (2008) Biochemistry 4th edition. United States of America: Lippincott Williams and Wilkins</ref>  
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Oxidative phosphorylation is one of the ATP generating processes in the cell. Understanding of this operation is based on chemiosmotic hypothesis (or Mitchell hypothesis) which clarifies how the free energy from electron transport chain across the inner mitochondrial membrane is used to produce ATP. <ref />
  
Mitochondrial inner membrane is embedded with four electron transferring complexes which work together as electron transport chain. Each complex is adapted to accept, oxidize and pass electrons to the next carrier of the chain. Main electron donors are NADH or FAD(2H). Firstly electrons from NADH are transported by complex I (NADH dehydrogenase), then CoQ (coanzyme Q), complex III (cytochrome b-c1 complex), cytochrome c, and complex IV (cytochrome oxydase). While electrons are transferring, the same complexes works as proton pumps and pump protons from the mitochondrial matrix to the intermembrane space where electrochemical potential gradient (Δp) are created. This gradient generates energy essential for ATP synthesis to be driven. Δp stimulates protons to reenter into the mitochondrial matrix through ATP synthase, which forms ATP from ADP and Pi<ref>Michael Lieberman, Allan D.Marks, Colleen Smith (2007)Marks' ESSENTIALS of Medical Biochemistry A Clinical Approach. United States of America:Lippincott Williams and Wilkins</ref><br>
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Mitochondrial inner membrane is embedded with four electron transferring complexes which work together as electron transport chain. Each complex is adapted to accept, oxidize and pass electrons to the next carrier of the chain. Main electron donors are NADH or FAD(2H). Firstly electrons from NADH are transported by complex I (NADH dehydrogenase), then CoQ (coanzyme Q), complex III (cytochrome b-c1 complex), cytochrome c, and complex IV (cytochrome oxydase). While electrons are transferring, the same complexes works as proton pumps and pump protons from the mitochondrial matrix to the intermembrane space where electrochemical potential gradient (Δp) are created. This gradient generates energy essential for ATP synthesis to be driven. Δp stimulates protons to reenter into the mitochondrial matrix through ATP synthase, which forms ATP from ADP and Pi.<ref />  
  
 
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<references />Pamela C.Champe, Richard A.Harvey, Denise r.Ferrier (2008) Biochemistry 4th edition. United States of America: Lippincott Williams and Wilkins
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<references />Pamela C.Champe, Richard A.Harvey, Denise r.Ferrier (2008) Biochemistry 4th edition. United States of America: Lippincott Williams and Wilkins<br>
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<references />Michael Lieberman, Allan D.Marks, Colleen Smith (2007) Marks' ESSENTIALS of Medical Biochemistry A Clinical Approach. United States of America:Lippincott Williams and Wilkins

Revision as of 18:04, 8 January 2011

Oxidative phosphorylation is one of the ATP generating processes in the cell. Understanding of this operation is based on chemiosmotic hypothesis (or Mitchell hypothesis) which clarifies how the free energy from electron transport chain across the inner mitochondrial membrane is used to produce ATP. Cite error: Invalid <ref> tag; refs with no content must have a name

Mitochondrial inner membrane is embedded with four electron transferring complexes which work together as electron transport chain. Each complex is adapted to accept, oxidize and pass electrons to the next carrier of the chain. Main electron donors are NADH or FAD(2H). Firstly electrons from NADH are transported by complex I (NADH dehydrogenase), then CoQ (coanzyme Q), complex III (cytochrome b-c1 complex), cytochrome c, and complex IV (cytochrome oxydase). While electrons are transferring, the same complexes works as proton pumps and pump protons from the mitochondrial matrix to the intermembrane space where electrochemical potential gradient (Δp) are created. This gradient generates energy essential for ATP synthesis to be driven. Δp stimulates protons to reenter into the mitochondrial matrix through ATP synthase, which forms ATP from ADP and Pi.Cite error: Invalid <ref> tag; refs with no content must have a name


Pamela C.Champe, Richard A.Harvey, Denise r.Ferrier (2008) Biochemistry 4th edition. United States of America: Lippincott Williams and Wilkins

Michael Lieberman, Allan D.Marks, Colleen Smith (2007) Marks' ESSENTIALS of Medical Biochemistry A Clinical Approach. United States of America:Lippincott Williams and Wilkins

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