P-glycoprotein

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The P-glycoprotein is part of the [[ABC Superfamily|ABC superfamily]]&nbsp;and is involved in drug efflux and therefore multi-drug resistance. The [[ABC Superfamily|ABC superfamily can]] be divided into seven subfamilies, P-glycoprotein being a member of the subfamily [[MDR/TAP|MDR/TAP]]&nbsp;<ref>Reversion of resistance to immunosuppressive agents in three patients with psoriatic arthritis by cyclosporine A. Andrea Picchianti Diamanti. 2010. PubMed.</ref>.&nbsp;P-glycoprotein can be inhibited by [[Cyclosporine A|cyclosporine A]] and [[Verapamil|verapamil]].<br>  
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The P-glycoprotein is part of the [[ABC Superfamily|ABC superfamily]]&nbsp;and is involved in drug efflux and therefore multi-drug resistance. The [[ABC_Superfamily|ABC superfamily]] can be divided into seven subfamilies, P-glycoprotein being a member of the subfamily [[MDR/TAP|MDR/TAP]]&nbsp;<ref>Reversion of resistance to immunosuppressive agents in three patients with psoriatic arthritis by cyclosporine A. Andrea Picchianti Diamanti. 2010. PubMed.</ref>.&nbsp;P-glycoprotein can be inhibited by [[Cyclosporine A|cyclosporine A]] and [[Verapamil|verapamil]].<br>  
  
=== References<br> ===
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=== References<br> ===
  
 
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Revision as of 22:05, 22 November 2010

The P-glycoprotein is part of the ABC superfamily and is involved in drug efflux and therefore multi-drug resistance. The ABC superfamily can be divided into seven subfamilies, P-glycoprotein being a member of the subfamily MDR/TAP [1]. P-glycoprotein can be inhibited by cyclosporine A and verapamil.

References

  1. Reversion of resistance to immunosuppressive agents in three patients with psoriatic arthritis by cyclosporine A. Andrea Picchianti Diamanti. 2010. PubMed.
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