P-glycoprotein

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The P-glycoprotein is part of the ABC superfamily and is involved in drug efflux and therefore multi-drug resistance. The ABC superfamily can be divided into seven subfamilies, P-glycoprotein being a member of the subfamily MDR/TAP [1]. P-glycoprotein can be inhibited by cyclosporine A and verapamil.

References

  1. Reversion of resistance to immunosuppressive agents in three patients with psoriatic arthritis by cyclosporine A. Andrea Picchianti Diamanti. 2010. PubMed.
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