P21

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P21 is an example of a cyclin-dependent kinase inhibitor (CKI). P21 protein inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4/6 complexes, and therefore functions acts as a modulator of cell cycle in turn determining wheteher progression at G1 and S phase will occur.
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P21 is an example of a [[cyclin-dependent kinase|cyclin-dependent kinase]] inhibitor (CKI). P21 protein inhibits the activity of [[cyclin-CDK2|cyclin-CDK2]], [[cyclin-CDK1|-<span style="font-size: 13.28px;">C</span>]]<span style="font-size: 13.28px;">[[cyclin-CDK1|DK1]], and [[cyclin-CDK4/6|-CDK4/6]] complexes, and therefore functions acts as a modulator of [[cell cycle|cell cycle]] in turn determining wheteher progression at G1 and S phase will occur</span><ref>Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (November 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805–16. doi:10.1016/0092-8674(93)90499-G. PMID 8242751</ref><span style="font-size: 13.28px;">.</span>
  
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=== References ===
  
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Reference:
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Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (November 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805–16. doi:10.1016/0092-8674(93)90499-G. PMID 8242751
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Revision as of 09:16, 10 December 2018

P21 is an example of a cyclin-dependent kinase inhibitor (CKI). P21 protein inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4/6 complexes, and therefore functions acts as a modulator of cell cycle in turn determining wheteher progression at G1 and S phase will occur[1].

References

  1. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (November 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805–16. doi:10.1016/0092-8674(93)90499-G. PMID 8242751


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