Penicilllin

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Penicillin is an [[Antibiotic|antibiotic]] that is used to treat [[Bacterial infection|bacterial infections]]. Penicillin kills susceptible [[Bacteria|bacteria]] by specifi<ref>M.Lobanovska and G.Pilla. Penicillin's discovery and Antibiotic resistance: Lessons for the future? Yale J biol Med. 2017, 90(1):135-145</ref>cally inhibiting the [[Transpeptidase|transpeptidase]] that catalyzes the final step in [[Cell wall|cell wall]] biosynthesis, the [[Cross linking|cross-linking]] of [[Peptidoglycan|peptidoglycan]]<ref>The Journal of Biological Chemistry. Vol.255, No 9, issue of May 10, pp. 3977-3986, 1980</ref>. Penicillin was first identified by [[Alexander Fleming|Alexander Fleming]] when he accidentally left the lid of one of his [[Petri dish|petri dishes]] open and returned to find the ''[[Penicillin notatum|Penicillin notatum]]'' [[Fungi|fungi]] developing on the dish generating Penicillin. .  
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Penicillin is an [[Antibiotic|antibiotic]] that is used to treat [[Bacterial infection|bacterial infections]]. Penicillin kills susceptible [[Bacteria|bacteria]] by specifically inhibiting the [[Transpeptidase|transpeptidase]] that catalyzes the final step in [[Cell wall|cell wall]] biosynthesis, the [[Cross linking|cross-linking]] of [[Peptidoglycan|peptidoglycan]]. Penicillin was first identified by [[Alexander Fleming|Alexander Fleming]] when he accidentally left the lid of one of his [[Petri dish|petri dishes]] open and returned to find the ''[[Penicillin notatum|Penicillin notatum]]'' [[Fungi|fungi]] developing on the dish generating Penicillin. .  
  
 
=== References  ===
 
=== References  ===
  
 
M.Lobanovska and G.Pilla. Penicillin's discovery and Antibiotic resistance: Lessons for the future? Yale J biol Med. 2017, 90(1):135-145<br>
 
M.Lobanovska and G.Pilla. Penicillin's discovery and Antibiotic resistance: Lessons for the future? Yale J biol Med. 2017, 90(1):135-145<br>

Revision as of 12:26, 17 October 2018

Penicillin is an antibiotic that is used to treat bacterial infections. Penicillin kills susceptible bacteria by specifically inhibiting the transpeptidase that catalyzes the final step in cell wall biosynthesis, the cross-linking of peptidoglycan. Penicillin was first identified by Alexander Fleming when he accidentally left the lid of one of his petri dishes open and returned to find the Penicillin notatum fungi developing on the dish generating Penicillin. .

References

M.Lobanovska and G.Pilla. Penicillin's discovery and Antibiotic resistance: Lessons for the future? Yale J biol Med. 2017, 90(1):135-145

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