Phagocytosis

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Phagocytosis is the process by which a [[Cell|cell]] engulfs solid material. The [[Molecule|molecule]] is then internalized in a&nbsp;vesicle of plasma membrane ([[Phagosome|phagosome]]) which fuses with a [[Lysosome|lysosome]] for destruction, any undigested remains of the molecule (eg. [[Bacteria|bacterium]]) are removed by [[Exocytosis|exocytosis]] and the products of digestion are absorbed into the cytoplasm. It occurs in the [[Immune system|immune system]], and is carried out by [[Phagocytes|phagocytes]] such as [[Macrophage|macrophages]] which are involved in the [[Innate immune response|innate immune response]]&nbsp;<ref>http://www.ncbi.nlm.nih.gov/pubmed/10358769</ref>.  
 
Phagocytosis is the process by which a [[Cell|cell]] engulfs solid material. The [[Molecule|molecule]] is then internalized in a&nbsp;vesicle of plasma membrane ([[Phagosome|phagosome]]) which fuses with a [[Lysosome|lysosome]] for destruction, any undigested remains of the molecule (eg. [[Bacteria|bacterium]]) are removed by [[Exocytosis|exocytosis]] and the products of digestion are absorbed into the cytoplasm. It occurs in the [[Immune system|immune system]], and is carried out by [[Phagocytes|phagocytes]] such as [[Macrophage|macrophages]] which are involved in the [[Innate immune response|innate immune response]]&nbsp;<ref>http://www.ncbi.nlm.nih.gov/pubmed/10358769</ref>.  
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The process of phagocytosis involves the macrophage beginning to encase the pathogen via endocytosis. Once the macrophage has engulfed the pathogen via endocytosis, the pathogen is in a phagosome. The pathogen then is broken down by the fusion of the phagocytic vesicle (phagosome) and the lysosome vesicles which contain oxidase and proteases, this process is called phagolysosome. <ref>http://courses.washington.edu/conj/bloodcells/phagocytosis.htm</ref> [[Image:Phagocytosis.jpg|thumb|right]]<br>
  
 
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=== Also see  ===
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Revision as of 00:02, 15 November 2013

Phagocytosis is the process by which a cell engulfs solid material. The molecule is then internalized in a vesicle of plasma membrane (phagosome) which fuses with a lysosome for destruction, any undigested remains of the molecule (eg. bacterium) are removed by exocytosis and the products of digestion are absorbed into the cytoplasm. It occurs in the immune system, and is carried out by phagocytes such as macrophages which are involved in the innate immune response [1].

The process of phagocytosis involves the macrophage beginning to encase the pathogen via endocytosis. Once the macrophage has engulfed the pathogen via endocytosis, the pathogen is in a phagosome. The pathogen then is broken down by the fusion of the phagocytic vesicle (phagosome) and the lysosome vesicles which contain oxidase and proteases, this process is called phagolysosome. [2]
Phagocytosis.jpg

Also see

Endocytosis

Pinocytosis

References

  1. http://www.ncbi.nlm.nih.gov/pubmed/10358769
  2. http://courses.washington.edu/conj/bloodcells/phagocytosis.htm



 

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