Pharmacotherapy of Cystic Fibrosis

From The School of Biomedical Sciences Wiki
(Difference between revisions)
Jump to: navigation, search
(Created page with '== Pharmacotherapy of Cystic Fibrosis == Pharmacotherapy relates to the use of chemical drugs to regulate and improve the function of defective CFTR channels…')
 
Line 1: Line 1:
== Pharmacotherapy of Cystic Fibrosis ==
+
== Pharmacotherapy of Cystic Fibrosis ==
  
Pharmacotherapy relates to the use of chemical drugs to regulate and improve the function of defective [[Cystic_fibrosis|CFTR]] channels.
+
Pharmacotherapy relates to the use of chemical drugs to regulate and improve the function of defective [[Cystic fibrosis|CFTR]] channels.<br>
  
 +
===== Potentiators  =====
  
 +
Example VX-770
  
===== Potentiators =====
+
Attempt to correct Class III and Class IV [[CFTR|CFTR]] mutations by increasing the conductance of the [[CFTR|CFTR]] channel.
  
Example VX-770
+
===== Correctors  =====
  
Attempt to correct Class III and Class IV CFTR mutations by increasing the conductance of the CFTR channel.
+
Example Trimethyl-oxide
  
===== Correctors =====
+
Attempt to correct Class II [[CFTR|CFTR]] mutations by improving the trafficking of [[CFTR|CFTR]] channels to the [[Lipid bi-layer|Cell Membrane]].
 
+
Example Trimethyl-oxide
+
 
+
Attempt to correct Class II CFTR mutations by improving the trafficking of CFTR channels to the [[Lipid bi-layer|Cell Membrane]].
+

Revision as of 17:03, 8 November 2010

Pharmacotherapy of Cystic Fibrosis

Pharmacotherapy relates to the use of chemical drugs to regulate and improve the function of defective CFTR channels.

Potentiators

Example VX-770

Attempt to correct Class III and Class IV CFTR mutations by increasing the conductance of the CFTR channel.

Correctors

Example Trimethyl-oxide

Attempt to correct Class II CFTR mutations by improving the trafficking of CFTR channels to the Cell Membrane.

Personal tools
Namespaces
Variants
Actions
Navigation
Toolbox