Phosphofructokinase

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PFK is an [[Allosteric enzyme|allosteric enzyme]]; meaning that its action is regulated by activator and inhibitor effector molecules; in this case [[AMP|AMP]] and [[ATP|ATP]] respectively.   
 
PFK is an [[Allosteric enzyme|allosteric enzyme]]; meaning that its action is regulated by activator and inhibitor effector molecules; in this case [[AMP|AMP]] and [[ATP|ATP]] respectively.   
  
Phosphofructokinase has antagonistic action with the enzyme [[Fructose 1,6-bisphosphatase|Fructose 1,6-bisphosphatase]]; a dephosphorylator.<ref>Berg J, Tymoczko J, Stryer L, Clarke N. Biochemistry. New York: W.H. Freeman; 2002.</ref>&nbsp;
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Phosphofructokinase has antagonistic action with the enzyme [[Fructose 1,6-bisphosphatase|Fructose 1,6-bisphosphatase]]; a dephosphorylator.<ref>Berg J, Tymoczko J, Stryer L, Clarke N. Biochemistry. New York: W.H. Freeman; 2002.</ref><br><br><references />&nbsp;

Revision as of 14:11, 3 December 2017

Phosphofructokinase (PFK) is a fundamental enzyme in the glycolytic pathway. As the name suggests, the enzyme acts on the intermediate compound 'phosphofructose'; its proper name being fructose-6-phosphate. The suffix 'kinase' indicates its function as a phosphorylator. The product of this enzyme-subtrate interaction is fructose 1,6 bisphosphate, which subsequently is hydrolysed to glyceralaldehyde 3 phosphate and dihydroxyacetone phosphate[1]

PFK is an allosteric enzyme; meaning that its action is regulated by activator and inhibitor effector molecules; in this case AMP and ATP respectively. 

Phosphofructokinase has antagonistic action with the enzyme Fructose 1,6-bisphosphatase; a dephosphorylator.[2]

  1. Phosphofructokinase - an overview | ScienceDirect Topics [Internet]. Sciencedirect.com. 2017 [cited 3 December 2017]. Available from: http://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/phosphofructokinase
  2. Berg J, Tymoczko J, Stryer L, Clarke N. Biochemistry. New York: W.H. Freeman; 2002.
 
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