Post-translation modification

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Post-translational modification (PTM) is the process in which a [[protein|protein]] is modified after [[protein biosynthesis|protein biosynthesis]].  
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 Post-translational modification (PTM) is the process in which a protein is modified after protein biosynthesis.  
  
PTM is specific and it is mainly catalysed by enzymes.There are many types of modification, such as [[Phosphorylation|phosphorylation]], [[Acetylation|acetylation]], [[Hydroxylation|hydroxylation]] ,[[Hydroxylation|methylation]], [[Glycosylation|glycosylation]],&nbsp;AMPylation, lipidation, [[Ubiquitination|ubiquitination]], proteolysis and [[Deamination|deamidation]]<ref>P Surat P. Types of Protein Post-Translational Modification [Internet]. News-Medical.net. 2018 [cited 19 October 2018]. Available from: https://www.news-medical.net/life-sciences/Types-of-Protein-Post-Translational-Modification.aspx</ref>.
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PTM is important for cellular functions. It is found to be involved in [[Cell signalling|cell signalling]], protein folding, [[Immune response|immune response]] and protein stability<ref>Theillet, F.-X., Smet-Nocca, C., Liokatis, S., Thongwichian, R., Kosten, J., Yoon, M.-K., … Selenko, P. (2012). Cell signaling, post-translational protein modifications and NMR spectroscopy. Journal of Biomolecular NMR, 54(3), 217–236. http://doi.org/10.1007/s10858-012-9674-x</ref>.<br>  
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PTM is specific and it is mainly catalysed by enzymes.There are many types of modification, such as [[Phosphorylation|phosphorylation]], [[Acetylation|acetylation]], [[Hydroxylation|hydroxylation]] ,[[Hydroxylation|methylation]], [[Glycosylation|glycosylation]],&nbsp;AMPylation, lipidation, [[Ubiquitination|ubiquitination]], proteolysis and [[Deamination|deamidation]]&nbsp;<ref>P Surat P. Types of Protein Post-Translational Modification [Internet]. News-Medical.net. 2018 [cited 19 October 2018]. Available from: https://www.news-medical.net/life-sciences/Types-of-Protein-Post-Translational-Modification.aspx</ref><span style="font-size: 13.28px;">.</span>
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PTM is important for cellular functions.It is found to be involved in [[Cell signalling|cell signalling]], protein folding, [[Immune response|immune response]] and protein stability<ref>Theillet, F.-X., Smet-Nocca, C., Liokatis, S., Thongwichian, R., Kosten, J., Yoon, M.-K., … Selenko, P. (2012). Cell signaling, post-translational protein modifications and NMR spectroscopy. Journal of Biomolecular NMR, 54(3), 217–236. http://doi.org/10.1007/s10858-012-9674-x</ref><span style="font-size: 13.28px;">.</span>
  
 
=== References  ===
 
=== References  ===
  
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Revision as of 05:08, 23 October 2018

 Post-translational modification (PTM) is the process in which a protein is modified after protein biosynthesis.


PTM is specific and it is mainly catalysed by enzymes.There are many types of modification, such as phosphorylation, acetylation, hydroxylation ,methylation, glycosylation, AMPylation, lipidation, ubiquitination, proteolysis and deamidation [1].


PTM is important for cellular functions.It is found to be involved in cell signalling, protein folding, immune response and protein stability[2].

References

  1. P Surat P. Types of Protein Post-Translational Modification [Internet]. News-Medical.net. 2018 [cited 19 October 2018]. Available from: https://www.news-medical.net/life-sciences/Types-of-Protein-Post-Translational-Modification.aspx
  2. Theillet, F.-X., Smet-Nocca, C., Liokatis, S., Thongwichian, R., Kosten, J., Yoon, M.-K., … Selenko, P. (2012). Cell signaling, post-translational protein modifications and NMR spectroscopy. Journal of Biomolecular NMR, 54(3), 217–236. http://doi.org/10.1007/s10858-012-9674-x


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