Post-translation modification

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Post-translational modification (PTM) is the process in which a protein is modified after protein biosynthesis.

PTM is specific and it is mainly catalysed by enzymes.There are many types of modification, such as phosphorylation, acetylation, hydroxylation ,methylation, glycosylation, AMPylation, lipidation, ubiquitination, proteolysis and deamidation[1].

PTM is important for cellular functions. It is found to be involved in cell signalling, protein folding, immune response and protein stability[2].


  1. P Surat P. Types of Protein Post-Translational Modification [Internet]. 2018 [cited 19 October 2018]. Available from:
  2. Theillet, F.-X., Smet-Nocca, C., Liokatis, S., Thongwichian, R., Kosten, J., Yoon, M.-K., … Selenko, P. (2012). Cell signalling, post-translational protein modifications and NMR spectroscopy. Journal of Biomolecular NMR, 54(3), 217–236.

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