Pre Initiation Complex
Pre Initiation Complex (PIC)
For polymerase II the PIC is far more complex. It consists of 6 General Transcription Factors (GTF). TFIID is the core recognition protein and binds to the TATA box. TFIIA stabilizes the binding complex. TFIID intreacts with TFIIB which brings in the RNA polymerase II which has TFIIF attached to it. This allows TFIIE and finally TFIIH to bind. TFIIH has helicase activity and starts seperating the strands at the Open Complex. Further it has CTD Kinase activity and facilitates DNA repair.
- ↑ Cassimeris,L. et al., 2007; p219 Lewin's cells. 2nd ed. Sudbury: Jones and Bartlett.