Premature Stop Codon

From The School of Biomedical Sciences Wiki
(Difference between revisions)
Jump to: navigation, search
 
Line 1: Line 1:
== Premature Stop Codons <br>  ==
 
 
 
A Premature Stop [[Codon|Codon]] is a sequence [[Mutation|mutation]] type (such as a [[Frameshift Mutation|Frameshift Mutation]])&nbsp;that results in the&nbsp;coding&nbsp;of a Stop&nbsp;[[Codon|Codon]]&nbsp;prematurely in the [[Reading frame|reading frame]]. <br>  
 
A Premature Stop [[Codon|Codon]] is a sequence [[Mutation|mutation]] type (such as a [[Frameshift Mutation|Frameshift Mutation]])&nbsp;that results in the&nbsp;coding&nbsp;of a Stop&nbsp;[[Codon|Codon]]&nbsp;prematurely in the [[Reading frame|reading frame]]. <br>  
  
Line 9: Line 7:
 
== Consequences of Premature Stop Codons  ==
 
== Consequences of Premature Stop Codons  ==
  
The&nbsp;addition&nbsp;of an unwanted Stop&nbsp;Codon cuts a [[Ribosome|Ribosome's]] process of&nbsp;Polypeptide Synthesis along&nbsp;an [[MRNA|mRNA]]&nbsp;Strangd short, resulting in fragmented incomplete [[Polypeptide|Polypeptide]] strands. These fragmented Polypeptide strands&nbsp;do not&nbsp;undergo succesful structural folding&nbsp;to form the appropriate [[Secondary_structure|Secondary]], [[Tertiary_structure|Tertiary]] and even [[Quaternary Structure|Quaternary Structures]] of the originally-intented [[Protein|Protein]],&nbsp;typically&nbsp;creating stumped or Truncated&nbsp;Proteins which&nbsp;often affects the function of the [[Proteins|protein]] by various pathways.
+
The&nbsp;addition&nbsp;of an unwanted Stop&nbsp;Codon cuts a [[Ribosome|Ribosome's]] process of&nbsp;Polypeptide Synthesis along&nbsp;an [[MRNA|mRNA]]&nbsp;Strangd short, resulting in fragmented incomplete [[Polypeptide|Polypeptide]] strands. These fragmented Polypeptide strands&nbsp;do not&nbsp;undergo succesful structural folding&nbsp;to form the appropriate [[Secondary structure|Secondary]], [[Tertiary structure|Tertiary]] and even [[Quaternary Structure|Quaternary Structures]] of the originally-intented [[Protein|Protein]],&nbsp;typically&nbsp;creating stumped or Truncated&nbsp;Proteins which&nbsp;often affects the function of the [[Proteins|protein]] by various pathways.

Latest revision as of 18:50, 13 November 2011

A Premature Stop Codon is a sequence mutation type (such as a Frameshift Mutation) that results in the coding of a Stop Codon prematurely in the reading frame.

Frequency

Premature Stop Codons are common in sequence mutations as 3 out of the 64 Codons in the Universal Codon Code programme for a Stop Codon. Coupling this with the often random nature of sequence mutations, this generates an average Premature Stop Codon creation of 1 in every 20 Codon mutations, a very common frequency within the already small Mutation Frequency of even simple Prokaryotic life, let alone higher Eukaryotes.

Consequences of Premature Stop Codons

The addition of an unwanted Stop Codon cuts a Ribosome's process of Polypeptide Synthesis along an mRNA Strangd short, resulting in fragmented incomplete Polypeptide strands. These fragmented Polypeptide strands do not undergo succesful structural folding to form the appropriate Secondary, Tertiary and even Quaternary Structures of the originally-intented Protein, typically creating stumped or Truncated Proteins which often affects the function of the protein by various pathways.

Personal tools
Namespaces
Variants
Actions
Navigation
Toolbox