Prions

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Not all infectious diseases are transmitted by bacteria or [[Virus|viruses]].&nbsp;Some neurological diseases, such as [[Creutzfeldt-Jaakob disease (CJD)|Creutzfeldt-Jaakob disease (CJD)]]&nbsp;or mad cow disease are in fact caused by agents called '''Prions, '''which are of similar size to viruses but are made up of only [[Protein|protein]] <ref name="null">J. M. Berg et. al (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref>&nbsp;  
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Not all infectious diseases are transmitted by bacteria or [[Virus|viruses]].&nbsp;Some neurological diseases, such as [[Creutzfeldt-Jaakob disease (CJD)|Creutzfeldt-Jaakob disease (CJD)]]&nbsp;or mad cow disease are in fact caused by agents called '''Prions, '''which are of similar size to viruses but are made up of only [[Protein|protein]] <ref>J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref>&nbsp;  
  
 
'''Prions '''have these characteristics:  
 
'''Prions '''have these characteristics:  
  
1.) "The transmissible agent consists of aggregated forms of a specific protein" <ref>J. M. Berg et. al (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref>  
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1.) "The transmissible agent consists of aggregated forms of a specific protein" <ref>J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref>.
  
2.) These protein aggregates cannot be degraded by the agents that degrade most other proteins <ref>J. M. Berg et. al (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref>  
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2.) These [[Protein|protein]] aggregates cannot be degraded by the agents that degrade most other proteins <ref>J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref>.
  
3.) "The protein is largely or completely derived from a cellular protein called PrP, that is normally present in the brain" <ref>J. M. Berg et. al (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref>  
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3.) "The protein is largely or completely derived from a cellular protein called PrP, that is normally present in the brain" <ref>J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref>.
  
So an aggregated form of a protein (that is already present in the brain) is the infectious agent in prion diseases <ref name="null">J. M. Berg et. al (2007) p 54, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref><br>  
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So an aggregated form of a protein (that is already present in the brain) is the infectious agent in prion diseases <ref>J. M. Berg et al. (2007) p 54, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref>.<br>  
  
 
=== References  ===
 
=== References  ===
  
=== <references /> ===
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<references />

Revision as of 15:50, 9 January 2011

Not all infectious diseases are transmitted by bacteria or viruses. Some neurological diseases, such as Creutzfeldt-Jaakob disease (CJD) or mad cow disease are in fact caused by agents called Prions, which are of similar size to viruses but are made up of only protein [1] 

Prions have these characteristics:

1.) "The transmissible agent consists of aggregated forms of a specific protein" [2].

2.) These protein aggregates cannot be degraded by the agents that degrade most other proteins [3].

3.) "The protein is largely or completely derived from a cellular protein called PrP, that is normally present in the brain" [4].

So an aggregated form of a protein (that is already present in the brain) is the infectious agent in prion diseases [5].

References

  1. J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company
  2. J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company
  3. J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company
  4. J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company
  5. J. M. Berg et al. (2007) p 54, Biochemistry, Sixth edition, New York, W.H. Freeman and Company
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