Proinsulin

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Proinsulin is the precursor to insulin. It is synthesised by the pancreas within the cells which make up the the Islets of Langerhans. Proinsulin is formed from pre-proinsulin when the signal peptide is cleaved off, and successively mature insulin is formed when the C peptide is cleaved via endoproteases from proinsulin[1].

Without proinsulin, insulin would not be able to be generated which would cause a wide range of disorders and illnesses within humans. 

References

  1. https://en.wikipedia.org/wiki/Proinsulin
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