Prostacyclin

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Prostacyclin (also called PGI2) is a prostaglandin belonging to the eicosanoid family[1], produced by intact vascular endothelial cells[2]. When prostacyclin is produced, it prevents platelet adhesion and aggregation so that clots are not unintentionally formed within blood vessels[3]. When the endothelium lining blood vessels is damaged, prostacyclin production is stopped and platelet aggregation occurs, allowing a clot to form and seal the break[4]. Prostacyclin is also a vasodilator[5]

References  

  1. https://en.wikipedia.org/wiki/Prostacyclin
  2. Silverthorn U.D., Johnson B.R., Ober W.C., Garrison C.W., Silverthorn A.C., 'Human Physiology: An Integrated Approach', 6th Edition, Pearson Education, 2013
  3. Silverthorn U.D., Johnson B.R., Ober W.C., Garrison C.W., Silverthorn A.C., 'Human Physiology: An Integrated Approach', 6th Edition, Pearson Education, 2013
  4. Silverthorn U.D., Johnson B.R., Ober W.C., Garrison C.W., Silverthorn A.C., 'Human Physiology: An Integrated Approach', 6th Edition, Pearson Education, 2013
  5. Silverthorn U.D., Johnson B.R., Ober W.C., Garrison C.W., Silverthorn A.C., 'Human Physiology: An Integrated Approach', 6th Edition, Pearson Education, 2013

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