Proteomics

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Proteomics is the study of&nbsp; total proteins which is expressed by a cell, tissue&nbsp;or an organism<ref name="null">Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics. 4 , 137. USA :Elsevier.</ref>. Meanwhile, genomics is the study of structure and roles of the whole gene products<ref name="null">Primrose S.B. , Twyman R.M. (2003). Principle of Genome Analysis and Genomics. 3, 9. Hong Kong: Graphicraft Limited.</ref>. There are a few&nbsp;crucial&nbsp;differences between proteomics and genomics. In biological fluids such as plasma, serum, urine, cells and tissues, a marker called as "Proteomic biomarkers" is used to mark the molecules<ref>Primrose S.B. , Twyman R.M. (2003). Principle of Genome Analysis and Genomics. 3, 9. Hong Kong: Graphicraft Limited.</ref>. Besides, if there is a stimuli from the environment or surroundings, the proteome(proteins) will react with the stimuli and keep changing in constant<ref>Primrose S.B. , Twyman R.M. (2003). Principle of Genome Analysis and Genomics. 3, 9. Hong Kong: Graphicraft Limited.</ref>. Furthermore,&nbsp;in every cells or tissues, the proteome is different from each other due to different genes carried<ref>Primrose S.B. , Twyman R.M. (2003). Principle of Genome Analysis and Genomics. 3, 9. Hong Kong: Graphicraft Limited.</ref>. Existence of&nbsp; post-translational modifications and protein conformation will cause in addition of the complexity<ref>Primrose S.B. , Twyman R.M. (2003). Principle of Genome Analysis and Genomics. 3, 9. Hong Kong: Graphicraft Limited.</ref>. Thus, only Polymerase Chain Reaction(PCR)&nbsp; produces total of proteome faster and ease to amplify them to an assay<ref>Primrose S.B. , Twyman R.M. (2003). Principle of Genome Analysis and Genomics. 3, 9. Hong Kong: Graphicraft Limited.</ref>. These reasons proves that the proteome potrays the transcriptome more than the genome itself<ref>Primrose S.B. , Twyman R.M. (2003). Principle of Genome Analysis and Genomics. 3, 9. Hong Kong: Graphicraft Limited.</ref>.
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Proteomics is the study of total [[Protein|proteins]] which is expressed by a [[Cell|cell]], tissue&nbsp;or an [[Organism|organism]]<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. It can also be defined as the study of the [[Proteome|proteome]]. The proteome is the total set of [[Protein|proteins]] encoded by the [[Genome|genome]] of an [[Organism|organism]].&nbsp;Meanwhile, [[Genomics|genomics]] is the study of structure and roles of the whole [[Gene|gene]] products<ref>Primrose S.B. , Twyman R.M. (2003). Principle of Genome Analysis and Genomics, 3rd Edition, Hong Kong: Graphicraft Limited. Page 9</ref>. There are a few&nbsp;crucial&nbsp;differences between proteomics and [[Genomics|genomics]]. In biological fluids such as [[Plasma|plasma]], [[Serum|serum]], [[Urine|urine]], cells and tissues, a marker called as "Proteomic biomarkers" is used to mark the [[Molecules|molecules]]<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. Besides, if there is a stimuli from the environment or surroundings, the proteome (proteins) will react with the stimuli and keep changing in constant<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. In certain diseases or stages of development, the protein complement of a cell may change, and comparing the proteomes of cells can be helpful in understanding what is happening to that cell. Furthermore,&nbsp;in every cells or tissues, the proteome is different from each other due to different genes carried<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. Existence of [[Post-translational modification|post-translational modifications]] and protein conformation will cause in addition of the complexity<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. Thus, only Polymerase Chain Reaction ([[PCR]])&nbsp; produces total of proteome faster and ease to amplify them to an assay<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. These reasons proves that the proteome potrays the transcriptome more than the genome itself<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>.<br>
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=== Reference  ===
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<references />

Latest revision as of 13:48, 18 October 2017

Proteomics is the study of total proteins which is expressed by a cell, tissue or an organism[1]. It can also be defined as the study of the proteome. The proteome is the total set of proteins encoded by the genome of an organism. Meanwhile, genomics is the study of structure and roles of the whole gene products[2]. There are a few crucial differences between proteomics and genomics. In biological fluids such as plasma, serum, urine, cells and tissues, a marker called as "Proteomic biomarkers" is used to mark the molecules[3]. Besides, if there is a stimuli from the environment or surroundings, the proteome (proteins) will react with the stimuli and keep changing in constant[4]. In certain diseases or stages of development, the protein complement of a cell may change, and comparing the proteomes of cells can be helpful in understanding what is happening to that cell. Furthermore, in every cells or tissues, the proteome is different from each other due to different genes carried[5]. Existence of post-translational modifications and protein conformation will cause in addition of the complexity[6]. Thus, only Polymerase Chain Reaction (PCR)  produces total of proteome faster and ease to amplify them to an assay[7]. These reasons proves that the proteome potrays the transcriptome more than the genome itself[8].

Reference

  1. Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137
  2. Primrose S.B. , Twyman R.M. (2003). Principle of Genome Analysis and Genomics, 3rd Edition, Hong Kong: Graphicraft Limited. Page 9
  3. Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137
  4. Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137
  5. Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137
  6. Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137
  7. Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137
  8. Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137
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