Proteomics
From The School of Biomedical Sciences Wiki
(Difference between revisions)
| Line 1: | Line 1: | ||
| − | Proteomics is the study of total [[ | + | Proteomics is the study of total [[Protein|proteins]] which is expressed by a [[Cell|cell]], tissue or an [[Organism|organism]]<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. Meanwhile, [[Genomics|genomics]] is the study of structure and roles of the whole [[Gene|gene]] products<ref>Primrose S.B. , Twyman R.M. (2003). Principle of Genome Analysis and Genomics, 3rd Edition, Hong Kong: Graphicraft Limited. Page 9</ref>. There are a few crucial differences between proteomics and genomics. In biological fluids such as plasma, serum, urine, cells and tissues, a marker called as "Proteomic biomarkers" is used to mark the molecules<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. Besides, if there is a stimuli from the environment or surroundings, the proteome (proteins) will react with the stimuli and keep changing in constant<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. Furthermore, in every cells or tissues, the proteome is different from each other due to different genes carried<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. Existence of post-translational modifications and protein conformation will cause in addition of the complexity<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. Thus, only Polymerase Chain Reaction ([[PCR]]) produces total of proteome faster and ease to amplify them to an assay<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. These reasons proves that the proteome potrays the transcriptome more than the genome itself<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>.<br> |
=== Reference === | === Reference === | ||
<references /> | <references /> | ||
Revision as of 11:02, 4 December 2015
Proteomics is the study of total proteins which is expressed by a cell, tissue or an organism[1]. Meanwhile, genomics is the study of structure and roles of the whole gene products[2]. There are a few crucial differences between proteomics and genomics. In biological fluids such as plasma, serum, urine, cells and tissues, a marker called as "Proteomic biomarkers" is used to mark the molecules[3]. Besides, if there is a stimuli from the environment or surroundings, the proteome (proteins) will react with the stimuli and keep changing in constant[4]. Furthermore, in every cells or tissues, the proteome is different from each other due to different genes carried[5]. Existence of post-translational modifications and protein conformation will cause in addition of the complexity[6]. Thus, only Polymerase Chain Reaction (PCR) produces total of proteome faster and ease to amplify them to an assay[7]. These reasons proves that the proteome potrays the transcriptome more than the genome itself[8].
Reference
- ↑ Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137
- ↑ Primrose S.B. , Twyman R.M. (2003). Principle of Genome Analysis and Genomics, 3rd Edition, Hong Kong: Graphicraft Limited. Page 9
- ↑ Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137
- ↑ Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137
- ↑ Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137
- ↑ Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137
- ↑ Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137
- ↑ Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137
