Pyruvate Dehydrogenase Complex

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Pyruvate Dehydrogenase Complex is a multi [[Enzyme|enzyme]] complex which converts [[pyruvate|pyruvate]] to [[acetyl-CoA|acetyl-CoA]] and CO<sub>2</sub>. The complex consists of 3 enzymes;  
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Pyruvate Dehydrogenase Complex is a multi [[Enzyme|enzyme]] complex which catalyzes the&nbsp;conversion of&nbsp;[[Pyruvate|pyruvate]] to [[Acetyl-CoA|acetyl-CoA]] and CO<sub>2</sub>. It is important in [[Metabolism|metabolism]]&nbsp;as&nbsp;it is the linking step&nbsp;between [[Glycolysis|glycolysis]]&nbsp;and the [[citric acid cycle|citric acid&nbsp;cycle]].&nbsp;The complex consists of 3 enzymes;  
  
*[[lipoamide reductase-transacetylase|lipoamide reductase-transacetylase]]
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*[[Lipoamide reductase-transacetylase|lipoamide reductase-transacetylase]]  
*[[dihydrolipoyl dehydrogenase|dihydrolipoyl dehydrogenase]]
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*[[Dihydrolipoyl dehydrogenase|dihydrolipoyl dehydrogenase]]  
*[[pyruvate decarboxylase|pyruvate decarboxylase]]
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*[[Pyruvate decarboxylase|pyruvate decarboxylase]]
  
The enzymes form a channel passing the reaction intermediates directly from one [[Enzyme|enzyme]] to the next.
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The enzymes form a channel in the [[mitrochondrial matrix|mitrochondrial matrix]], passing the reaction intermediates directly from one [[Enzyme|enzyme]] to the next. This increases the efficiecy of the enzmes as the intermediate substances are unstable, therefore having the enzymes close together allows for maximum production of acetyl-CoA.

Revision as of 18:36, 12 November 2010

Pyruvate Dehydrogenase Complex is a multi enzyme complex which catalyzes the conversion of pyruvate to acetyl-CoA and CO2. It is important in metabolism as it is the linking step between glycolysis and the citric acid cycle. The complex consists of 3 enzymes;

The enzymes form a channel in the mitrochondrial matrix, passing the reaction intermediates directly from one enzyme to the next. This increases the efficiecy of the enzmes as the intermediate substances are unstable, therefore having the enzymes close together allows for maximum production of acetyl-CoA.

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