Pyruvate decarboxylase

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Revision as of 19:06, 12 November 2010

Pyruvate decarboxylase is an enzyme which removes a CO2 molecule from pyruvate to give an acetaldehyde, and is notably the first enzyme in the pyruvate dehydrogenase complex. It is a heterotetramer consisting of 2 alpha and 2 beta subunits. The alpha subunits are encoded by PDHA1 gene which is located on Xp22.2-p22.1, the beta subunits are encoded by the PDHB gene, which is located on chromosone 3p. The active site for the enzyme is contained on the alpha subunit. 

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