Pyruvate decarboxylase

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Pyruvate decarboxylase is an enzyme which removes a CO2 molecule from pyruvate to give an acetaldehyde, and is notably the first enzyme in the pyruvate dehydrogenase complex. It is a heterotetramer consisting of 2 alpha and 2 beta subunit. The alpha subunits are encoded by PDHA1 gene which is located on Xp22.2-p22.1, the beta subunits are encoded by the PDHB gene, which is located on chromosone 3p. Brown et al., (1994) discovered that the active site for the enzyme is contained on the alpha subunit.

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